A Mendelian randomization study on the association of bone mineral density with periodontitis

Yu, Yang; Chu, Tengda; Dong, Jingya; Deng, Hui; Pan, Yihuai; Wang, Yi

doi:10.1111/odi.14582

Cited by 2 publications

(2 citation statements)

References 62 publications

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“…Due to insufficient variables for FA BMD, MR-Presso analysis could not be conducted. Nevertheless, the MR multi-effect residual P-value exceeded 0.05, and the identified Instrumental Variables (IVs) have been previously applied in related MR studies ( 32 , 33 ). Furthermore, screening conditions from the same database with p < 5E-6, r2 < 0.001, and kb = 10000 were employed to obtain additional FA BMD IVs (16 SNPs).…”

Section: Resultsmentioning

confidence: 99%

Osteoporosis and coronary heart disease: a bi-directional Mendelian randomization study

Zhang,

Xu,

Liu

et al. 2024

Front. Endocrinol.

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BackgroundOsteoporosis (OP) and cardiovascular disease (CVD) are major global public health issues, especially exacerbated by the challenges of an aging population. As these problems intensify, the associated burden on global health is expected to increase significantly. Despite extensive epidemiological investigations into the potential association between OP and CVD, establishing a clear causal relationship remains elusive.MethodsInstrumental variables were selected from summary statistics of the IEU GWAS database. Five different components of BMD (heel BMD, LS BMD, FA BMD, FN BMD, and TB BMD) were used as OP phenotypes. CHD, MI, and stroke were selected to represent CVD. Multiple analysis methods were used to evaluate the causal relationship between CVD and OP comprehensively. In addition, sensitivity analyses(Cochran’s Q test, MR-Egger intercept test, and “leave one out” analysis) were performed to verify the reliability of the results.ResultsThe MR showed a significant causal relationship between CHD on heel BMD and TB BMD; in the reverse analysis, there was no evidence that OP has a significant causal effect on CVD. The reliability of the results was confirmed through sensitivity analysis.ConclusionThe study results revealed that CHD was causally associated with Heel BMD and TB BMD, while in the reverse MR analysis, the causal relationship between OP and CVD was not supported. This result posits CHD as a potential etiological factor for OP and prompts that routine bone density assessment at traditional sites (forearm, femoral neck, lumbar spine) using DAX may inadequately discern underlying osteoporosis issues in CHD patients. The recommendation is to synergistically incorporate heel ultrasound or DAX for total body bone density examinations, ensuring clinical diagnostics are both precise and reliable. Moreover, these findings provide valuable insights for public health, contributing to the development of pertinent prevention and treatment strategies.

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Section: Resultsmentioning

confidence: 99%

Osteoporosis and coronary heart disease: a bi-directional Mendelian randomization study

Zhang,

Xu,

Liu

et al. 2024

Front. Endocrinol.

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“…There is also supporting evidence from Mendelian randomization studies, which indicate no causal effect of osteoporosis on periodontitis. 36,37 The discrepancy of the impact of functional thyroid disease on periodontitis may be due to the failure of sufficient adjustment for confounding.…”

Section: Discussionmentioning

confidence: 99%

Periodontitis and thyroid function: A bidirectional Mendelian randomization study

Gao,

Huang,

Liu

et al. 2024

J of Periodontal Research

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Background and ObjectivePrevious studies suggest interaction between periodontitis and thyroid function, while the causality has not yet been established. We applied the Mendelian randomization (MR) method to assess bidirectional causal association between periodontitis and thyroid‐related traits, including free thyroxine (FT4), thyroid stimulating hormone (TSH), hypothyroidism, hyperthyroidism and autoimmune thyroid disease (AITD).MethodsGenetic instruments were extracted from large‐scale genome‐wide association studies on normal‐range FT4 (N = 49 269) and TSH (N = 54 288) levels, TSH in full range (N = 119 715); hypothyroidism (discovery/replication cohorts: N = 53 423/334 316), hyperthyroidism (discovery/replication cohorts: N = 51 823/257 552), AITD (N = 755 406) and periodontitis (N = 45 563). Here, the inverse variance weighted (IVW) method was applied as the primary analysis, and robustness of results were assessed by several pleiotropic‐robust methods. Results were adjusted for Bonferroni correction thresholds with significant p < .004 (0.05/13) and suggestive p between .004 and .05.ResultsThe IVW analysis revealed a suggestively causal linkage between genetic predisposition to periodontitis and the increased risk of hypothyroidism (discovery cohort: odds ratio [OR] = 1.24, 95% confidence interval [CI] = 1.05–1.46, p = .012; replication cohort: OR = 1.06, 95% CI = 1.01–1.11, p = .011). No evidence was found for supporting the impact of periodontitis on hyperthyroidism and AITD risks (associated p ≥ .209), as well as thyroid‐related traits on periodontitis risk (associated p ≥ .105). These findings were robust and consistent through sensitivity analysis with other MR models.ConclusionThis bidirectional MR reveals periodontitis should not be attributed to variations in thyroid function but it has potential causal effect on hypothyroidism risk, which provides a better understanding of the relationship between periodontitis and thyroid function, and potential evidence for the clinical intervention of hypothyroidism. Further investigations are warranted to elucidate the nature and underlying mechanisms of this finding.

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A Mendelian randomization study on the association of bone mineral density with periodontitis

Cited by 2 publications

References 62 publications

Osteoporosis and coronary heart disease: a bi-directional Mendelian randomization study

Osteoporosis and coronary heart disease: a bi-directional Mendelian randomization study

Periodontitis and thyroid function: A bidirectional Mendelian randomization study

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