A Mental Syndrome Associated with Lung Carcinoma

McGovern, Garrett

doi:10.1001/archneurpsyc.1959.02340150073008

Cited by 14 publications

(1 citation statement)

References 12 publications

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“…Charatan and Brierley (1956), who reported three cases of bronchial carcinoma with toxic confusional psychosis, considered that extensive liver metastases were a causative factor. But McGovern, Miller and Robertson (1959) described two cases with mental changes in which there were no liver metastases and I have also examined a similar case. Savage and Noble (1954) reported two cases of pancreatic carcinoma with a psychiatric illness, reviewed the literature and found that 26 similar cases had previously been described; the mental changes are apparently not related to interference with insulin secretion.…”

Section: Carcinomatous Neuromyopathymentioning

confidence: 99%

Neurological Disorders Associated with Malignant Disease

1961

Postgraduate Medical Journal

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Section: Carcinomatous Neuromyopathymentioning

confidence: 99%

Neurological Disorders Associated with Malignant Disease

1961

Postgraduate Medical Journal

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Peripheral Neuropathy in Bronchogenic Carcinoma

Boruchow¹,

Sanders²,

Pabico³

et al. 1962

Arch Intern Med

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Thalamic Degeneration, Dementia, and Seizures

Daniels¹

1969

Arch Neurol

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ATIENTS harboring malignant neoplasms may develop neurological and endocrinological disorders in the absence of metastases to the nervous system or endocrine glands.1 The resulting clinical syndromes have beenreferred to as the "remote" or "nonmetastatic" effects of malignant tumors. The exact incidence of these complications has not been determined. Croft and Wilkinson2 state that nonmetastatic neurological syndromes develop in 2% to 16% of carcinomas, and of these, 65% are neuromuscular in type. The incidence of neurological involvement is highest with pulmonary malignancies. Although hypotheses implicating infectious, nutritional immunological, metabolic, and toxic factors have been suggested.1,3-7 the precise biological basis of these remote effects has not been determined.We provide here a clinical and anatomical report of a man who presented with dementia, developed inappropriate secretion of the antidiuretic hormone (ADH), and died six months later in status epilepticus. General autopsy revealed a bronchogenic carcinoma which had not metastasized to the nervous system or endocrine glands. The combination of remote neurological and endocrine complications in the same patient is very rare.8·9 Yet this inconstancy is such, As thou too shalt adore; I could not love thee, dear, so much Loved I not honour more.-Richard Lovelace

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A Mental Syndrome Associated with Lung Carcinoma

Cited by 14 publications

References 12 publications

Neurological Disorders Associated with Malignant Disease

Neurological Disorders Associated with Malignant Disease

Peripheral Neuropathy in Bronchogenic Carcinoma

Thalamic Degeneration, Dementia, and Seizures

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