A mesenchymal stem cell-derived nanovesicle-biopotentiated bovine serum albumin-bridged gelatin hydrogel for enhanced diabetic wound therapy

Wu, Yan; Meng, Sheng; Zhang, Shihao; Xiao, Lan; Xiao, Yin; Zhang, Mengya; Bei, Ying; Li, Meiyun; Zhang, Fan; Qi, Yuan; Wu, Shao-Yi; Liu, Jianyong; Li, Haitao; Yuan, Xiaohuan; Li, Meng; Li, Yulin; Gao, Jie

doi:10.1016/j.matdes.2023.111960

Cited by 19 publications

(4 citation statements)

References 73 publications

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“…As a natural delivery method, the greatly extended circulation and malignant cells-specific features of stem cells have generated intense interest for producing several biomimetic delivery systems. 181,182 To increase tumor targeting and extend circulation time, it is possible to encapsulate nanoparticles using natural cell membranes to meet the objective of cell imitation. 88,183 These nanoparticles acquire the overall biofunctions of actual cell membranes.…”

Section: Recent Applications Of Biomimetic Exosomes For Cancer Photot...mentioning

confidence: 99%

Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

Raza,

Zafar,

Jiang

et al. 2024

Biomater. Sci.

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Section: Recent Applications Of Biomimetic Exosomes For Cancer Photot...mentioning

confidence: 99%

Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

Raza,

Zafar,

Jiang

et al. 2024

Biomater. Sci.

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“…[ 80 ]). Refractory wounds, such as diabetic skin ulcers, can cause serious health problems [ 187 , 188 ]. Previous studies have validated the role of autophagy in various phases of wound healing.…”

Section: The Application Of Autophagy-modulating Biomaterials In Tiss...mentioning

confidence: 99%

Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration

Wu,

Li,

Ning

et al. 2024

Cell Commun Signal

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Autophagy is a self-renewal mechanism that maintains homeostasis and can promote tissue regeneration by regulating inflammation, reducing oxidative stress and promoting cell differentiation. The interaction between biomaterials and tissue cells significantly affects biomaterial-tissue integration and tissue regeneration. In recent years, it has been found that biomaterials can affect various processes related to tissue regeneration by regulating autophagy. The utilization of biomaterials in a controlled environment has become a prominent approach for enhancing the tissue regeneration capabilities. This involves the regulation of autophagy in diverse cell types implicated in tissue regeneration, encompassing the modulation of inflammatory responses, oxidative stress, cell differentiation, proliferation, migration, apoptosis, and extracellular matrix formation. In addition, biomaterials possess the potential to serve as carriers for drug delivery, enabling the regulation of autophagy by either activating or inhibiting its processes. This review summarizes the relationship between autophagy and tissue regeneration and discusses the role of biomaterial-based autophagy in tissue regeneration. In addition, recent advanced technologies used to design autophagy-modulating biomaterials are summarized, and rational design of biomaterials for providing controlled autophagy regulation via modification of the chemistry and surface of biomaterials and incorporation of cells and molecules is discussed. A better understanding of biomaterial-based autophagy and tissue regeneration, as well as the underlying molecular mechanisms, may lead to new possibilities for promoting tissue regeneration.

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“…In situ hydrogel systems composed of hyperbranched polyethylene glycol diacrylate (HB-PEGDA) polymers, sulfhydryl functionalized hyaluronic acid (HA-SH), and short RGD peptides bound to adipose-derived stem cells (ASCs) significantly enhanced neovascularization and accelerated wound healing [116]. With the aim of reducing scar formation, bone marrow mesenchymal stem cell (BMSC)-derived nanovesicles (NVs) released by hydrogels were enhanced by genipin and BSA, resulting in efficient ROS clearance and good immunomodulatory activity, and the promoted the proliferation and migration of fibroblasts and vascular endothelial cells, which effectively treated diabetic wounds [117]. Injectable hydrogels from adipose acellular matrix hydrogels (hDAT-gel) combined with human adipose stem cells (hASCs) can accelerate the formation of blood vessels at the wound site to a certain extent and accelerate wound healing, which has great potential in the field of wound healing [118].…”

Section: Stem Cell Delivery Into Skin Woundsmentioning

confidence: 99%

The Role and Prospects of Mesenchymal Stem Cells in Skin Repair and Regeneration

Wu,

Sun,

et al. 2024

Biomedicines

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Mesenchymal stem cells (MSCs) have been recognized as a cell therapy with the potential to promote skin healing. MSCs, with their multipotent differentiation ability, can generate various cells related to wound healing, such as dermal fibroblasts (DFs), endothelial cells, and keratinocytes. In addition, MSCs promote neovascularization, cellular regeneration, and tissue healing through mechanisms including paracrine and autocrine signaling. Due to these characteristics, MSCs have been extensively studied in the context of burn healing and chronic wound repair. Furthermore, during the investigation of MSCs, their unique roles in skin aging and scarless healing have also been discovered. In this review, we summarize the mechanisms by which MSCs promote wound healing and discuss the recent findings from preclinical and clinical studies. We also explore strategies to enhance the therapeutic effects of MSCs. Moreover, we discuss the emerging trend of combining MSCs with tissue engineering techniques, leveraging the advantages of MSCs and tissue engineering materials, such as biodegradable scaffolds and hydrogels, to enhance the skin repair capacity of MSCs. Additionally, we highlight the potential of using paracrine and autocrine characteristics of MSCs to explore cell-free therapies as a future direction in stem cell-based treatments, further demonstrating the clinical and regenerative aesthetic applications of MSCs in skin repair and regeneration.

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A mesenchymal stem cell-derived nanovesicle-biopotentiated bovine serum albumin-bridged gelatin hydrogel for enhanced diabetic wound therapy

Cited by 19 publications

References 73 publications

Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

Progress of cell membrane-derived biomimetic nanovesicles for cancer phototherapy

Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration

The Role and Prospects of Mesenchymal Stem Cells in Skin Repair and Regeneration

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