A meta-analysis of 18FDG-PET–CT, 18FDG-PET, MRI and bone scintigraphy for diagnosis of bone metastases in patients with lung cancer

Qu, Xinhua; Huang, Xiaolu; Yan, Weili; Wu, Lian‐Ming; Dai, Kerong

doi:10.1016/j.ejrad.2011.01.126

Cited by 169 publications

(93 citation statements)

References 30 publications

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“…The patient remains alive following the administration of multimodal therapy with thymosin (4 mg, twice a week) for 3 months and Traditional Chinese Medicine for 6 months. 18 FDG-PET-CT demonstrates increased diagnostic value (sensitivity and specificity) for the diagnosis of bone metastasis from lung cancer compared with alternative imaging methods (14).…”

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confidence: 99%

Effect of synchronous solitary bone metastasectomy and lung cancer resection on non-small cell lung cancer patients

Zhao

Gao

et al. 2016

Oncology Letters

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Abstract. Lung cancer is the most frequent cause of cancer-associated mortality among men and women globally. The skeleton is one of the most common metastatic sites. The majority of patients exhibiting bone metastases are treated using systemic therapy or symptom-based palliative approaches without surgery. The present study attempted to improve the therapeutic effects of synchronous surgeries in resectable non-small cell lung cancer patients exhibiting solitary bone metastasis. A total of 5 patients underwent synchronous lung cancer resections and solitary bone metastasectomies between October 2009 and November 2011 in the Department of Cardiothoracic Surgery, Shanghai Sixth People's Hospital (Shanghai, China). All patients had received fluorodeoxyglucose positron emission tomography-computed tomography or bone scintigraphy to demonstrate the presence of solitary bone metastasis and to exclude the presence of metastases at alternative sites. The patients received standard lung cancer and mediastinal lymph node resections. In addition, bone lesions were assessed by orthopedists and operated on synchronously with standard procedures. Following surgery, all patients were administered standard chemotherapeutic regimens. Perioperative indicators, including time for thoracic drainage, length of hospital stay, incidence of post-operative complications and progression-free survival (PFS) time, were observed. The average time for post-operative drainage was 4.6±1.1 days, and the average length of post-operative hospitalization was 8.8±2.2 days. All procedures were performed safely with no serious complications. The PFS of the patients was 13.2±7.7 months. While 2 patients presenting with spinal metastases succumbed at ~1 year post-surgery, the remaining 3 patients presenting with limb bone metastases survived for >16 months post-surgery, and were alive at the last follow-up. In conclusion, the present study indicated that a synchronous metastasectomy and lung tumor resection is a safe method of treatment. The PFS time and survival results demonstrated that on the rare occasion that a patient exhibits solitary bone metastasis, aggressive surgical treatment may be a potential therapeutic option.

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confidence: 99%

Effect of synchronous solitary bone metastasectomy and lung cancer resection on non-small cell lung cancer patients

Zhao

Gao

et al. 2016

Oncology Letters

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“…This single study, which is performed to characterise the lung tumor itself, provides information about, among others, the mediastinal lymph node status and can exclude adrenal and bone metastasis. FDG PET/CT is more accurate in detecting bone metastasis in comparison to CT, MRI and bone scintigraphy [5][6][7]. In most hospitals FDG PET/CT is performed from skull base (sometimes from the cranium) to the groin.…”

Section: Discussionmentioning

confidence: 99%

“…FDG PET/ CT is more accurate in detecting bone metastasis in comparison to bone scintigraphy [5], CT [6] and MRI [7]. The other common site of dissemination, the brain, is imaged by MRI, due to the high sensitivity and specificity in comparison to FDG PET/CT [8].…”

Section: Introductionmentioning

confidence: 99%

Solitary Bone Metastasis Appearing outside the Usual Range of FDG PET/CT in Stage III Lung Cancer: Is Total Body FDG PET/CT Imaging Mandatory?

Fanggiday¹,

Uyterlinde²,

Heuvel³

et al. 2012

J Nucl Med Radiat Ther

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Nowadays, 18-fluorodeoxyglucose positron emission tomography (18-FDG/PET) and computed tomography (CT) are frequently used in the diagnosis and staging of lung cancer. Usually, FDG-PET/CT images are taken from cranium or skull base to the groin, which covers most of the potential locations of metastasis. We describe three cases of stage IIIB NSCLC with unexpected stage-changing solitary bone metastasis outside the usual range of FDG PET/CT. We discuss whether a total body PET/CT should be performed on a regular basis. In addition, we propose a practical solution that is applicable in each clinic, to assess the whole body "on demand", without compromising the logistics in a busy PET/CT clinic.

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“…The protocol used in the present meta-analysis was conducted as described in our previous studies (6,7,29) and based on recommendations in the methodological guidelines for conducting systematic reviews studying diagnostic accuracy (30) and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (31).…”

Section: Methodsmentioning

confidence: 99%

“…GS is also commonly used in the diagnosis of PJI, particularly in developing countries, as a result of its low cost, rapid turnaround time and ease of use; however, its value remains controversial due to conflicting results on the effectiveness of GS in the diagnosis of PJI (5,(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). The present meta-analysis was therefore performed as one of a series of meta-analyses (6,7,29) in order to evaluate the detection validity of GS for the diagnosis of PJI and to provide evidence-based advice to clinicians.…”

Section: Introductionmentioning

confidence: 99%

Limitations of Gram staining for the diagnosis of infections following total hip or knee arthroplasty

Ouyang

Zhai

Qin

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The diagnosis of prosthetic joint infection (PJI)following total joint arthroplasty is difficult for clinicians to make decisions due to the similar symptoms presented by aseptic loosening and infection. Gram staining (GS) is a widely used test but its value remains controversial due to conflicting results in the diagnosis of PJI. The aim of the present study was therefore to evaluate the value of GS in the diagnosis of PJI. Searches using MEDLINE, EMBASE and OVID databases were conducted for data published between January 1990 and December 2013. Meta-analysis was used to pool the sensitivity, specificity, diagnostic odd ratios (DORs), area under the receiveroperating characteristic curve (AUC), positive-likelihood ratios (PLRs), negative-likelihood ratios (NLRs) and post-test probability. The heterogeneity and publication bias were assessed, and subgroup and meta-regression analyses were conducted. A total of 18 studies, including a total of 4,647 patients, were selected for analysis. The pooled sensitivity and specificity values for the diagnosis of PJI were 0.19 and 1.00, respectively. The AUC, PLR and NLR were 0.89, 41.6 and 0.82, respectively. Subgroup analyses indicated that the sensitivity/specificity for total hip arthroplasty was 0.14/0.99, whereas that for total knee arthroplasty was 0.14/1.00. Synovial fluid best reflected accurate GS-based diagnoses, with the highest DOR of 242, whereas tissue had the highest AUC of 0.96 (95% CI, 0.94-0.97). GS had a poor clinically acceptable diagnostic value for detecting PJI. These data do not support the routine use of GS, without additional proof of infection, for diagnosing PJI; instead, GS could be used as an adjuvant tool to support the results of other investigations.

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A meta-analysis of 18FDG-PET–CT, 18FDG-PET, MRI and bone scintigraphy for diagnosis of bone metastases in patients with lung cancer

Cited by 169 publications

References 30 publications

Effect of synchronous solitary bone metastasectomy and lung cancer resection on non-small cell lung cancer patients

Effect of synchronous solitary bone metastasectomy and lung cancer resection on non-small cell lung cancer patients

Solitary Bone Metastasis Appearing outside the Usual Range of FDG PET/CT in Stage III Lung Cancer: Is Total Body FDG PET/CT Imaging Mandatory?

Limitations of Gram staining for the diagnosis of infections following total hip or knee arthroplasty

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