2019
DOI: 10.1007/s00774-019-01025-9
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A meta-analysis of bone morphogenetic protein-2 versus iliac crest bone graft for the posterolateral fusion of the lumbar spine

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Cited by 18 publications
(14 citation statements)
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“…Nonhuman primate noninstrumented models represent a challenging environment to evaluate because of excessive motion from the lack of posterior instrumentation in these active animals with highly mobile spines. The cumulative reported success rate for ICBG in this model is 22.2% (2 of 9 ICBG-treated motion segments [Table IV]) compared with 75% to 83% reported in metanalyses of ICBG-augmented instrumented PLF [17][18][19][20][21][22][23][24][25]37,[44][45][46][47] and 55% to 97% for ICBG-augmented noninstrumented PLF [80][81][82][83][84][85] in humans. The use of posterior instrumentation would likely have improved success rates for the 0.15-mg/cm 3 BV-265/CM or 0.075-mg/cm 3 BV-265/PCM combinations.…”
Section: Discussionmentioning
confidence: 81%
“…Nonhuman primate noninstrumented models represent a challenging environment to evaluate because of excessive motion from the lack of posterior instrumentation in these active animals with highly mobile spines. The cumulative reported success rate for ICBG in this model is 22.2% (2 of 9 ICBG-treated motion segments [Table IV]) compared with 75% to 83% reported in metanalyses of ICBG-augmented instrumented PLF [17][18][19][20][21][22][23][24][25]37,[44][45][46][47] and 55% to 97% for ICBG-augmented noninstrumented PLF [80][81][82][83][84][85] in humans. The use of posterior instrumentation would likely have improved success rates for the 0.15-mg/cm 3 BV-265/CM or 0.075-mg/cm 3 BV-265/PCM combinations.…”
Section: Discussionmentioning
confidence: 81%
“…Over the next several years these issues were investigated extensively through new prospective studies, analysis of large databases, and systematic reviews. The vast majority of the subsequent studies reported complication rates similar to the prior literature and repudiated the assertion that complications had been significantly underreported [16][17][18]. Importantly, numerous cohort and large database studies demonstrated no association between BMP use and increased cancer rate [19,20].…”
Section: Introductionmentioning
confidence: 81%
“…It may be difficult to achieve satisfactory arthrodesis in MIS settings [ 7 ]. Iliac crest autograft and BMP could be considered as available options to increase fusion potential in various spinal fusion surgeries [ 20 , 21 ]. Although autologous bone is considered the gold standard bone graft material, it is well known to be associated with several graft site morbidities, such as pain, hematoma formation, infection, and pelvic fracture [ 22 , 23 ].…”
Section: Discussionmentioning
confidence: 99%