A meta-analysis of cognitive performance in melancholic versus non-melancholic unipolar depression

Zaninotto, Leonardo; Solmi, Marco; Veronese, Nicola; Guglielmo, Riccardo; Ioime, Lucia; Camardese, Giovanni; Serretti, Alessandro

doi:10.1016/j.jad.2016.04.039

Cited by 55 publications

(37 citation statements)

References 77 publications

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“…As noted, there are concerns about the accuracy of SRQs (Soundy et al 2014) and our data may be underestimates or overestimates. Also, as indicated, people with depression are known to experience cognitive impairment (Zaninotto et al, 2016) which may make recall less accurate. Those factors may help to explain some of our counterintuitive results such as:1) people living in the community spent less time in total physical activity than mixed settings, with a difference of more than 300 minutes per day.…”

Section: Discussionmentioning

confidence: 99%

Physical activity and sedentary behavior in people with major depressive disorder: A systematic review and meta-analysis

Schuch

Vancampfort

Firth

et al. 2017

Journal of Affective Disorders

500

318

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Section: Discussionmentioning

confidence: 99%

Physical activity and sedentary behavior in people with major depressive disorder: A systematic review and meta-analysis

Schuch

Vancampfort

Firth

et al. 2017

Journal of Affective Disorders

500

318

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“…We hypothesized that mPFC‐projecting DR neurons from CORT‐treated rats would display an electrophysiological profile indicative of hypofunction relative to those from vehicle‐treated rats. While glucocorticoid abnormalities have been associated with deficits in visual memory tasks among depressed patients, these are believed to result from cortical dysfunction and decrements in attention and working memory, not visual sensory pathways (Pivonello et al., ; Zaninotto et al., ). Therefore, we expected that the effects of CORT‐treatment on LGN‐projecting neurons would be indicative of less functional change than those observed in mPFC‐projecting cells.…”

Section: Introductionmentioning

confidence: 99%

Selective vulnerability of dorsal raphe‐medial prefrontal cortex projection neurons to corticosterone‐induced hypofunction

Prouty

Chandler

Gao

et al. 2019

Eur J of Neuroscience

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Glucocorticoid hormones and serotonin (5‐HT) are strongly associated with the development and treatment of depression, respectively. Glucocorticoids regulate the function of serotonergic neurons in the dorsal raphe nucleus (DR), which are the major source of 5‐HT to the forebrain. DR 5‐HT neurons are electrophysiologically heterogeneous, though whether this phenotypic variation aligns with specific brain functions or neuropsychiatric disease states is largely unknown. The goal of this work was to determine if chronic exogenous glucocorticoid administration differentially affects the electrophysiological profile of DR neurons implicated in the regulation of emotion versus visual sensation by comparing properties of cells projecting to medial prefrontal cortex (mPFC) versus lateral geniculate nucleus (LGN). Following retrograde tracer injection into mPFC or LGN, male Sprague‐Dawley rats received daily injections of corticosterone (CORT) for 21 days, after which whole‐cell patch clamp recordings were made from retrogradely labeled DR neurons. CORT‐treatment significantly increased the action potential half‐width of LGN‐projecting DR neurons, but did not significantly affect the firing frequency or excitatory postsynaptic currents of these cells. CORT‐treatment significantly reduced the input resistance, evoked firing frequency, and spontaneous excitatory postsynaptic current frequency of mPFC‐projecting DR neurons, indicating a concurrent reduction of both intrinsic excitability and excitatory drive. Our results suggest that the serotonergic regulation of cognitive and emotional networks in the mPFC may be more sensitive to the effects of glucocorticoid excess than visual sensory circuits in the LGN and that reduced 5‐HT transmission in the mPFC may underlie the association between glucocorticoid excess and depression.

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“…Moreover, when there is a cognitive distortion of high-level executive functions such as reasoning and judgment, individuals become more susceptible to stress and more easily exposed to experiences of depression and anxiety 1 , 2 , 4 . However, most clinical studies have only explored group-wise correlations between depressive mood, anxiety, and experienced cognitive dysfunction, or have calculated quantitative differences in cognitive functioning ability between patients diagnosed with psychiatric disorder versus normal controls 5 – 7 .…”

Section: Introductionmentioning

confidence: 99%

Hubness of strategic planning and sociality influences depressive mood and anxiety in College Population

Yun

Choi

Kwon

et al. 2017

Sci Rep

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Depressive mood and anxiety can reduce cognitive performance. Conversely, the presence of a biased cognitive tendency may serve as a trigger for depressive mood-anxiety. Previous studies have largely focused on group-wise correlations between clinical-neurocognitive variables. Using network analyses for intra-individual covariance, we sought to decipher the most influential clinical-neurocognitive hub in the differential severity of depressive-anxiety symptoms in a college population. Ninety college students were evaluated for depressive-anxiety symptoms, Minnesota multiphasic personality inventory-2(MMPI-2), and neuro-cognition. Weighted and undirected version of the intra-individual covariance networks, comprised of 18 clinical-neurocognitive variables satisfied small-worldness and modular organization in the sparsity range of K = 0.20–0.21. Furthermore, betweenness centrality of perseverative error for the Wisconsin card sorting test was reduced in more depressive individuals; higher anxiety was related to the increased betweenness centrality of MMPI-2 clinical scale 0(Si). Elevated edge-betweenness centrality of covariance between the MMPI-2 clinical scale 7(Pt) versus commission error of the continuous performance test predicted more anxiety higher than depressive mood. With intra-individual covariance network of clinical-neurocognitive variables, this study demonstrated critical drivers of depressive mood[attenuated influence of strategic planning] or anxiety[domination of social introversion/extroversion, in addition to the influence of compulsivity-impulsivity covariance as a shortcut component among various clinical-neurocognitive features].

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A meta-analysis of cognitive performance in melancholic versus non-melancholic unipolar depression

Cited by 55 publications

References 77 publications

Physical activity and sedentary behavior in people with major depressive disorder: A systematic review and meta-analysis

Physical activity and sedentary behavior in people with major depressive disorder: A systematic review and meta-analysis

Selective vulnerability of dorsal raphe‐medial prefrontal cortex projection neurons to corticosterone‐induced hypofunction

Hubness of strategic planning and sociality influences depressive mood and anxiety in College Population

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