A meta-analysis of cortical inhibition and excitability using transcranial magnetic stimulation in psychiatric disorders

Radhu, Natasha; Jesus, Danilo Rocha de; Ravindran, Lakshmi N.; Zanjani, Anosha; Fitzgerald, Paul B.; Daskalakis, Zafiris J.

doi:10.1016/j.clinph.2013.01.014

Cited by 167 publications

(145 citation statements)

References 81 publications

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“…In summary, TBS paradigms primarily act on inhibitory interneurons and modulate GABAergic functions. Impairments in GABAergic interneurons in the frontal lobe and motor cortex (Benes, 2011;Benes and Berretta, 2001;Benes et al, 1991;Hashimoto et al, 2008), and reduced motor-cortical inhibition (reduced SICI) Radhu et al, 2013) are evident findings in schizophrenia. Therefore, impaired inhibitory functions in schizophrenia patients, more specifically represented by a reduced number of calbindin containing cells (Chance et al, 2005;Cotter et al, 2002), can be forward as a possible explanation of the different plasticity responses following cTBS.…”

Section: Tbs After-effects and Inhibitory Interneuron Activity In Schmentioning

confidence: 99%

Investigations of motor-cortex cortical plasticity following facilitatory and inhibitory transcranial theta-burst stimulation in schizophrenia: A proof-of-concept study

Hasan

Brinkmann

Strube

et al. 2015

Journal of Psychiatric Research

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Section: Tbs After-effects and Inhibitory Interneuron Activity In Schmentioning

confidence: 99%

Investigations of motor-cortex cortical plasticity following facilitatory and inhibitory transcranial theta-burst stimulation in schizophrenia: A proof-of-concept study

Hasan

Brinkmann

Strube

et al. 2015

Journal of Psychiatric Research

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“…Compromised cortical activity of neuropsychiatric patients, associated with hypo-dopaminergic states (Stahl 2013) and neurophysiological inhibitory deficits (Radhu et al 2013), may explain these findings. It thus remains possible that TMS primarily offers neuronal modulation of cortical networks only when abnormal activation patterns exist.…”

Section: Discussionmentioning

confidence: 89%

Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory

et al. 2016

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“…For instance, the effects of online TMS on behavior can turn from inhibitory to facilitatory whether the targeted brain area had been initially suppressed (Silvanto, Cattaneo, et al, 2008). It is reasonable to assume that the cortical activity of healthy vs. neuropsychiatric patients assessed in our study are different in many aspects, such as the clinical conditions assessed being associated with hypodopaminergic states (Stahl, 2009) and major depression and schizophrenia with inhibitory deficits as well (Radhu et al, 2013). Importantly, our review focused on the off-line rTMS effects on WMexperiments that, in fact, evaluate the after-effects of brain stimulation on WM.…”

Section: Discussionmentioning

confidence: 95%

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

Brunoni

Vanderhasselt

2014

Brain and Cognition

569

411

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Recent studies have used non-invasive brain stimulation (NIBS) techniques, such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS), to increase dorsolateral prefrontal cortex (DLPFC) activity and, consequently, working memory (WM) performance.. However, such experiments have yielded mixed results, possibly due to small sample sizes and heterogeneity of outcomes. Therefore, our aim was to perform a systematic review and metaanalyses on NIBS studies assessing the n-back task, which is a reliable index for WM. From the first data available to February 2013, we looked for sham-controlled, randomized studies that used NIBS over the DLPFC using the n-back task in PubMed/MEDLINE and other databases. Twelve studies (describing 33 experiments) matched our eligibility criteria. Active vs. sham NIBS was significantly associated with faster response times (RT), higher percentage of correct responses and lower percentage of error responses. However, meta-regressions showed that tDCS (vs. rTMS) presented an improvement only in RT. This could have occurred in part because almost all tDCS studies employed a crossover design (possibly more employed in tDCS over rTMS due to the reliable tDCS blinding) -this factor (study design) was also associated with no improvement in correct responses in the active vs. sham groups. To conclude, rTMS over the DLPFC significantly improved all measures of WM performance whereas tDCS significantly improved RT, but not the percentage of correct and error responses. Mechanistic insights on the role of DLPFC in WM are further discussed, as well as how NIBS techniques could be used in neuropsychiatric samples presenting WM deficits, such as major depression, dementia and schizophrenia.

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A meta-analysis of cortical inhibition and excitability using transcranial magnetic stimulation in psychiatric disorders

Cited by 167 publications

References 81 publications

Investigations of motor-cortex cortical plasticity following facilitatory and inhibitory transcranial theta-burst stimulation in schizophrenia: A proof-of-concept study

Investigations of motor-cortex cortical plasticity following facilitatory and inhibitory transcranial theta-burst stimulation in schizophrenia: A proof-of-concept study

Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex enhances working memory

Working memory improvement with non-invasive brain stimulation of the dorsolateral prefrontal cortex: A systematic review and meta-analysis

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