A meta‐analysis of depressive symptomatology and alcohol consumption over time<sup>*</sup>

Hartka, Elizabeth; Johnstone, Bryan M.; Leino, Eeva; Motoyoshi, M; Temple, Mark; Fillmore, Kaye Middleton

doi:10.1111/j.1360-0443.1991.tb01704.x

Cited by 182 publications

(123 citation statements)

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“…FHP women have a higher incidence of depression and lower incidence of alcoholism compared to FHP men suggesting that different pathophysiological mechanisms underlie alcoholism for men and women (Helzer and Pryzbeck 1988;Hartka et al 1991). One can speculate that the unique hormonal profile in FHP men compared to the other groups is somehow related to differences in the heritability of alcoholism for men and women.…”

Section: Discussionmentioning

confidence: 94%

Endogenous Opioid Activity Is Associated with Obsessive-Compulsive Symptomology in Individuals with a Family History of Alcoholism

Mangold

Peyrot

Giggey

et al. 2000

Neuropsychopharmacology

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Endogenous opioid activity has been associated with the regulation of mood and inhibition of the hypothalamicpituitary-adrenal (HPA) axis. We assessed differences in psychological symptomology and naloxone sensitivity in non-alcoholic males and females with a family history of alcoholism (FHP) and without a family history of alcoholism (FHN).Family history of alcohol dependence is a strong predictor of risk for the future development of alcoholism (Goodwin 1985;Cloninger 1981;McGue et al. 1992). Adult sons of alcoholic fathers have a three to four-fold higher risk for this disorder compared to the male offspring of non-alcoholic fathers (Schuckit 1981).These findings have led investigators to examine the presence of a wide range of possible psychological as well as neurobiological mediators for the development of alcoholism in individuals with a positive family history (FHP) for alcoholism (Pihl et al. 1990;Martin and Sher 1994;Baker and Stephenson 1995). A wide range of psychological differences have been specifically associated with FHP males relative to controls, including impulsivity (Saunders and Schuckit 1981;Schulsinger et al. 1985), conduct disorder (Nylander and Rydelius 1982), antisocial personality with or without hyperactivity (Alterman et al. 1983), attention deficit disorder (Gillen and Hesselbrock 1992;Deckel et al. 1995), and aggressiveness (Windle 1990 NO . 6 family history for alcoholism compared with normals (Newlin and Thomson 1990;Schuckit et al. 1988Schuckit et al. ,1996Waltman et al. 1994).A growing body of literature suggests that the endogenous opioid system modulates a wide range of psychological symptomology, as well as the functioning of the Hypothalamic-Pituitary-Adrenal (HPA) axis (Pickar et al. 1982;Olson et al. 1996). It has been speculated that the interplay between environmental and genetic determinants generates a spectrum of endogenous opioid activity in the human population which, in the extreme ranges of opioid expression, lead to disturbances in mood, behavior and neuroendocrine function (Wand et al. 1998;Wand 1999;Blevins et al. 1994). Major behavioral alterations have been induced by opioid blockade with naloxone, suggesting the involvement of the endogenous opioid system in the tonic regulation of mood, behavior and cognition in normal (Cohen et al. 1983;Martin del Campo et al. 1992) and psychiatric populations (Insel and Pickar 1983;Sandyk 1987;Pickar et al. 1982). Some clinical studies suggest that in addition to the serotonergic system, the opioidergic system may be implicated in obsessive-compulsive symptomology (Carrion 1995;Insel and Pickar 1983;Keuler et al. 1996;Rapoport et al. 1992). Plasma B-endorphin levels have been found to be significantly lower in OCD subjects than in controls (Weizman et al. 1990). Studies with OCD subjects have shown naloxone decreases obsessional doubt and compulsive behaviors at low doses (Insel and Pickar 1983;Keuler et al. 1996) and decreases at higher doses (Sandyk 1987) in a small subgroup of subjects. Furthermore, opioid agent...

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Section: Discussionmentioning

confidence: 94%

Endogenous Opioid Activity Is Associated with Obsessive-Compulsive Symptomology in Individuals with a Family History of Alcoholism

Mangold

Peyrot

Giggey

et al. 2000

Neuropsychopharmacology

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“…On the other hand, the findings seem to agree with the extant body of research on the issue. Thus, while a link between depression and heavier drinking has been found repeatedly [1][2][3][4], the association between anxiety and alcohol use seems less clear. It is true that both forms of emotional distress rarely have been assessed in one and the same study, but Skogen et al [49] recently reported that depressive symptoms were related to frequent intoxication among late teen youth, while symptoms of anxiety were not.…”

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Associations between emotional distress and heavy drinking among young people: A longitudinal study

Pape¹,

Norstrøm

2015

Drug and Alcohol Review

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IntroductionDepression has generally been found to be associated with heavy drinking and alcohol use disorders [1][2][3][4]. There is also evidence of a link between anxiety and extensive use of alcohol [5][6][7][8], but this association has been less extensively scrutinized and the findings seem less clear. Thus, some studies of young people report null-findings [9] or a link between anxiety and heavy drinking that is attributable to concurrent symptoms of depression and/or other confounding factors [10][11][12].The bulk of previous studies focus on severe forms of internalizing problems and harmful drinking, and have typically relied on diagnoses or other dichotomous measures. Obviously, such research may be of clinical significance, yet the findings do not necessarily apply to mild forms of emotional distress and non-pathological drinking [13]. To address subclinical conditions is important in its own right, not least because they may contribute to the total burden of harm and social cost at least as much as the clinical ones -simply by being far more prevalent.Furthermore, studies of adult samples predominate in the field, and the association between emotional distress and heavy drinking may be different among young people. The onset of drinking typically occurs in adolescence, and the consumption of alcohol and related harm escalate during the late teens and reaches a peak in early adulthood [14,15]. Problems related to mood and emotions also tend to increase in this period of life [16]. Moreover, it has been hypothesized that risk factors related to mental health may become increasingly important in influencing drinking behaviour as individuals approach adulthood, reflecting the challenges of leaving a protected environment, and entering an independent adult role [17].Indeed, a recent study showed that the association between depression and alcohol use disorders was stronger in early adulthood than in adolescence [18]. The present paper pursues this issue further by analysing four-wave panel data on less severe forms of emotional distress and heavy drinking from a general population study of young people.

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“…Some support for the role of MDEs as precursors of later alcohol disorders comes from follow-up studies of alcohol-related outcomes in individuals with earlier onset major depressions (e.g., Crum et al, 2008). On the other hand, at least one report noted a tendency for a decrease in alcohol use following depressive syndromes (Hartka et al, 1991), and several studies found no signifi cant increase in later AUDs for individuals with childhood and adolescent depressive episodes, while these same subjects demonstrated the expected increased risk for major depressions at follow-up (Ferguson and Woodward, 2002;Harrington et al, 1990;Rao et al, 1995;Weissman et al, 1999).…”

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confidence: 99%

Relationships Among Independent Major Depressions, Alcohol Use, and Other Substance Use and Related Problems Over 30 Years in 397 Families

Schuckit¹,

Smith²,

Kalmijn³

2013

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Although heavy drinking is related to sadness on multiple levels, the link between alcohol use disorders (AUDs) and major depressive episodes (MDEs) is more controversial. One complicating factor is that some MDEs are temporary and only occur in the context of heavy drinking, whereas other MDEs are longer lasting and occur independently of intense alcohol intake (i.e., independent depressive episodes [IDEs]). We hypothesized that a longitudinal study that uses validated interviews with subjects and relatives and distinguishes between IDEs and alcohol-induced depressive episodes would reveal little evidence of a link between IDEs and AUDs. Method: Histories of AUDs, IDEs, and substance-induced depressions were prospectively evaluated over 30 years in 397 male probands from the San Diego Prospective Study and in their 449 offspring using questions extracted from the Semi-Structured Assessment for the Genetics of Alcoholism interview. Results: The rate of IDEs over 30 years in the 397 probands was 15.3% overall. Among probands who developed AUDs, 31% of their depressive episodes were substance induced, not IDEs. For these men followed over 3 decades, those with IDEs had no increased rate of AUDs and evidenced no higher rate of use or abuse/dependence on illicit substances. Similar conclusions applied to their 449 offspring ages 12 years and older. Conclusions: These data support the importance of distinguishing between IDE and substance-induced depressions when evaluating the relationship between AUDs and depression syndromes. (J. Stud. Alcohol Drugs, 74, 271-279, 2013)

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A meta‐analysis of depressive symptomatology and alcohol consumption over time^*

Cited by 182 publications

References 24 publications

Endogenous Opioid Activity Is Associated with Obsessive-Compulsive Symptomology in Individuals with a Family History of Alcoholism

Endogenous Opioid Activity Is Associated with Obsessive-Compulsive Symptomology in Individuals with a Family History of Alcoholism

Associations between emotional distress and heavy drinking among young people: A longitudinal study

Relationships Among Independent Major Depressions, Alcohol Use, and Other Substance Use and Related Problems Over 30 Years in 397 Families

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A meta‐analysis of depressive symptomatology and alcohol consumption over time*

Cited by 182 publications

References 24 publications

Endogenous Opioid Activity Is Associated with Obsessive-Compulsive Symptomology in Individuals with a Family History of Alcoholism

Endogenous Opioid Activity Is Associated with Obsessive-Compulsive Symptomology in Individuals with a Family History of Alcoholism

Associations between emotional distress and heavy drinking among young people: A longitudinal study

Relationships Among Independent Major Depressions, Alcohol Use, and Other Substance Use and Related Problems Over 30 Years in 397 Families

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A meta‐analysis of depressive symptomatology and alcohol consumption over time^*