A meta-analysis of diffusion tensor imaging studies of the corpus callosum in schizophrenia

Patel, Shivani; Mahon, Katie; Wellington, Robin; Zhang, Jian-Ping; Chaplin, William F.; Szeszko, Philip R.

doi:10.1016/j.schres.2011.03.014

Cited by 88 publications

(61 citation statements)

References 88 publications

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“…Diminished connectivity in the CC may be involved in the pathophysiology of many neurodevelopmental disorders 18 and schizophrenia. 19 We previously reported that the CC area was larger in children with 22q11DS, compared with typically developing children, 20 replicated by others. [21][22][23] Relatively little is known about the association between the CC size and the neurocognitive/psychiatric manifestations of 22q11DS, with one report of an association between ADHD and smaller CC area 21 and another of faster enumeration skills with a larger CC.…”

Section: Introductionmentioning

confidence: 53%

Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms

et al. 2012

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Chromosome 22q11.2 deletion syndrome (22q11DS) is associated with neurocognitive impairments. The neural substrates of cognitive impairments in 22q11DS remain poorly understood. Because the corpus callosum (CC) is found to be abnormal in a variety of neurodevelopmental disorders, we obtained volumetric measurements of the CC and its subregions, examined the relationship between these regions and neurocognition and selected genotypes within candidate genes in the 22q11.2 interval in 59 children with 22q11DS and 53 control subjects. The total CC, splenium and genu were significantly larger in children with 22q11DS and the enlargement was associated with better neurocognitive functioning in the 22q11DS group, suggestive of a compensatory increase in the CC volumes. The expected age-related increase in the volume of the CC was not seen in children with 22q11DS, indicative of dysmaturation of the CC in these children. The increased volumes in the genu, splenium and total CC in the 22q11DS group were associated with polymorphisms within the candidate genes: COMT (rs4680), ZDHHC8 (rs175174) and UFD1L (rs5992403). These findings indicate that alterations in the CC volume in children with 22q11DS are associated with cognition and specific genotypes in the 22q11.2 interval.

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Section: Introductionmentioning

confidence: 53%

Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms

et al. 2012

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“…Four meta-analyses have been conducted on diffusion imaging findings in cross-sectional studies (Bora et al, 2011;Di et al, 2009;Ellison-Wright and Bullmore, 2009;Patel et al, 2011). The two earlier studies (Di et al, 2009;EllisonWright and Bullmore, 2009) performed meta-analyses of studies that used a voxel-based studies and detected deficits in the genu and splenium in one case (Ellison-Wright and Bullmore, 2009) but not in the other (Di et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The two earlier studies (Di et al, 2009;EllisonWright and Bullmore, 2009) performed meta-analyses of studies that used a voxel-based studies and detected deficits in the genu and splenium in one case (Ellison-Wright and Bullmore, 2009) but not in the other (Di et al, 2009). A recent study conducted two meta-analyses (Patel et al, 2011) to examine the genu and splenium of the corpus callosum in 213 controls and 202 patients and reported reduced FA in both regions that were significant in the splenium (effect size 0.53) but subthreshold for reduced FA for the genu (effect size 0.22). However, this study included only those studies (n ¼ 7) using a ROI approach.…”

Section: Discussionmentioning

confidence: 99%

Altered Interhemispheric and Temporal Lobe White Matter Microstructural Organization in Severe Chronic Schizophrenia

Holleran

Ahmed

Anderson‐Schmidt

et al. 2013

Neuropsychopharmacol

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Diffusion MRI investigations in schizophrenia provide evidence of abnormal white matter (WM) microstructural organization as indicated by reduced fractional anisotropy (FA) primarily in interhemispheric, left frontal and temporal WM. Using tract-based spatial statistics (TBSS), we examined diffusion parameters in a sample of patients with severe chronic schizophrenia. Diffusion MRI data were acquired on 19 patients with chronic severe schizophrenia and 19 age-and gender-matched healthy controls using a 64 gradient direction sequence, (b ¼ 1300 s/mm 2 ) collected on a Siemens 1.5T MRI scanner. Diagnosis of schizophrenia was determined by Diagnostic and Statistical Manual for Mental Disorders 4th Edition (DSM-IV) Structured Clinical Interview for DSM disorder (SCID). Patients were treatment resistance, having failed to respond to at least two antipsychotic medications, and had prolonged periods of moderate to severe positive or negative symptoms. Analysis of diffusion parameters was carried out using TBSS. Individuals with chronic severe schizophrenia had significantly reduced FA with corresponding increased radial diffusivity in the genu, body, and splenium of the corpus callosum, the right posterior limb of the internal capsule, right external capsule, and the right temporal inferior longitudinal fasciculus. There were no voxels of significantly increased FA in patients compared with controls. A decrease in splenium FA was shown to be related to a longer illness duration. We detected widespread abnormal diffusivity properties in the callosal and temporal lobe WM regions in individuals with severe chronic schizophrenia who have not previously been exposed to clozapine. These deficits can be driven by a number of factors that are indistinguishable using in vivo diffusion-weighted imaging, but may be related to reduced axonal number or packing density, abnormal glial cell arrangement or function, and reduced myelin.

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“…With the advent of DTI, it has become increasingly clear that the structure of the corpus callosum is impaired in several brain disorders. In a recent meta-analysis, for instance, Patel et al (2011) concluded that the splenium of the corpus callosum has significantly lower FA in patients with schizophrenia vs controls. Recent DTI studies have also identified callosal abnormalities in patients with other brain disorders such as bipolar disorder (Benedetti et al, 2011), post-traumatic stress disorder (Jackowski et al, 2008), and autism (Alexander et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…By mapping the diffusion of water through the brain's fibers, DTI can recover major fiber pathways in the brain, and patterns of anatomical connectivity, with broad applications in psychiatry, neurology, and brain mapping (Thomason and Thompson, 2011). DTI-based white matter abnormalities are widely reported in developmental and degenerative brain diseases including Alzheimer's disease and mild cognitive impairment (Fellgiebel et al, 2004;Naggara et al, 2006;Oishi et al, 2011), schizophrenia (White et al, 2008;Ellison-Wright and Bullmore, 2009;Patel et al, 2011), bipolar disorder (Sussmann et al, 2009;Heng et al, 2010), attention-deficit/hyperactivity disorder (Konrad and Eickhoff, 2010), and autism (Alexander et al, 2007;Ke et al, 2009). These studies show the utility of DTI in neuropsychiatric research.…”

Section: Introductionmentioning

confidence: 99%

Predicting White Matter Integrity from Multiple Common Genetic Variants

Kohannim

Jahanshad

Braskie

et al. 2012

Neuropsychopharmacol

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Several common genetic variants have recently been discovered that appear to influence white matter microstructure, as measured by diffusion tensor imaging (DTI). Each genetic variant explains only a small proportion of the variance in brain microstructure, so we set out to explore their combined effect on the white matter integrity of the corpus callosum. We measured six common candidate singlenucleotide polymorphisms (SNPs) in the COMT, NTRK1, BDNF, ErbB4, CLU, and HFE genes, and investigated their individual and aggregate effects on white matter structure in 395 healthy adult twins and siblings (age: 20-30 years). All subjects were scanned with 4-tesla 94-direction high angular resolution diffusion imaging. When combined using mixed-effects linear regression, a joint model based on five of the candidate SNPs (COMT, NTRK1, ErbB4, CLU, and HFE) explained B6% of the variance in the average fractional anisotropy (FA) of the corpus callosum. This predictive model had detectable effects on FA at 82% of the corpus callosum voxels, including the genu, body, and splenium. Predicting the brain's fiber microstructure from genotypes may ultimately help in early risk assessment, and eventually, in personalized treatment for neuropsychiatric disorders in which brain integrity and connectivity are affected.

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A meta-analysis of diffusion tensor imaging studies of the corpus callosum in schizophrenia

Cited by 88 publications

References 88 publications

Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms

Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms

Altered Interhemispheric and Temporal Lobe White Matter Microstructural Organization in Severe Chronic Schizophrenia

Predicting White Matter Integrity from Multiple Common Genetic Variants

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