A meta-analysis of neurofunctional imaging studies of emotion and cognition in major depression

Diener, Carsten; Kuehner, Christine; Brusniak, Wencke; Ubl, Bettina; Wessa, Michèle; Flor, Herta

doi:10.1016/j.neuroimage.2012.04.005

Cited by 379 publications

(252 citation statements)

References 86 publications

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“…PCr acts as a reservoir of high-energy phosphate in tissues with high metabolic demand like the brain. Metabolic studies utilizing FDG-PET and SPECT have shown both increases and decreases in glucose metabolism in the brains of patients with MDD (Baxter et al, 1989;Drevets et al, 1992;Mayberg et al, 1994) and fMRI studies show a similar bidirectional pattern (Diener et al, 2012). In an exploratory analysis gray matter PCr was increased in patients reporting higher scores on the somatization subscale of the SQ (primarily representing increased physical fatigue, aches, and pains).…”

Section: Discussionmentioning

confidence: 94%

Tissue Type-Specific Bioenergetic Abnormalities in Adults with Major Depression

Harper

Jensen

Ravichandran

et al. 2016

Neuropsychopharmacol

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Brain bioenergetic abnormalities have been observed frequently in adults with major depressive disorder (MDD); however, results have been inconsistent regarding whether decreased or increased metabolism was observed. Phosphorus-31 magnetic resonance spectroscopy (31P MRS) allows for the quantification of bioenergetic molecules, containing high-energy phosphates, over the whole brain as well as measuring the differences between gray matter and white matter. We recruited 50 subjects with a current diagnosis of MDD, not currently treated with psychotropic medication, between ages of 18 and 65 (mean ± SD age: 43.4 ± 13.6; 46% female) and 30 healthy volunteers, matched for age and gender (39.0 ± 12.5 years of age; 36.6% female). All subjects received a T1 MP-FLASH scan for tissue segmentation followed by 31P MRS, chemical shift imaging scan with 84 voxels of data collected over the entire brain utilizing a dual-tuned, protonphosphorus coil to minimize subject movement. Phosphocreatine and inorganic phosphate (Pi) varied in opposite directions across gray matter and white matter when MDD subjects were compared with controls. This finding suggests alterations in high-energy phosphate metabolism and regulation of oxidative phosphorylation in MDD patients. In addition, within the MDD group, gray matter Pi, a regulator of oxidative phosphorylation, correlated positively with severity of depression. These data support a model that includes changes in brain bioenergetic function in subjects with major depression.

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Section: Discussionmentioning

confidence: 94%

Tissue Type-Specific Bioenergetic Abnormalities in Adults with Major Depression

Harper

Jensen

Ravichandran

et al. 2016

Neuropsychopharmacol

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“…DLPFC plays an important role in working memory and executive function. When patients with depression implement working memory task, it involves abnormal brain activation of the frontal edge of the network like DLPFC and ACC (Diener et al, 2012).…”

Section: Functional Neuroimaging Of Working Memory In Patients With Dmentioning

confidence: 99%

Working Memory and Functional Neuroimaging in Patients with Depression

Chen¹,

Chen²,

Dai³

2015

PSYCH

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Numerous studies have demonstrated that patients suffering from depression present impairment in working memory. This paper firstly introduced the concept of working memory, and then elucidated the deficits of working memory of patients with depression. It also reviewed the neuroimaging studies of working memory in patients with depression. In the final part, we further summarized the future research orientations. In short, exploration of working memory on the regulative mechanisms of depression and figuring out that working memory impairment is the cause or the result of depressive symptoms will be the core problem that the future research needs to address.

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“…Recently, functional alterations in striatal structures (nucleus accumbens, caudate, putamen) have been related to altered reward and loss processing in depression [24]. Meta-analytic findings [25] emphasize that depression is characterized by predominantly reduced activity in the rostral anterior cingulate cortex and anterior insula, which is linked to altered salience processing of emotional and cognitive stimuli. In addition, hypersensitivity to negative information and reduced executive functioning seem substantially associated with a lack of prefrontal control in terms of both exaggerated frontal hypo-and hyperactivity.…”

Section: Behavioral and Neurobiological Models Of Depressionmentioning

confidence: 99%

“…Several lines of evidence point to medial prefrontal, limbic, and striato-pallidothalamic regions to be critically involved in the pathophysiology of MDD [27]. However, it needs to be mentioned that rather heterogeneous than homogeneous results for multiple cortical and subcortical regions characterize the current state on functional neuroimaging findings in major depression [25].…”

Section: Behavioral and Neurobiological Models Of Depressionmentioning

confidence: 99%