A Meta-Analysis of Sensory Modulation Symptoms in Individuals with Autism Spectrum Disorders

Ben‐Sasson, Ayelet; Hen, Liat; Fluss, Ronen; Cermak, Sharon A.; Engel‐Yeger, Batya; Gal, Eynat

doi:10.1007/s10803-008-0593-3

Cited by 807 publications

(687 citation statements)

References 23 publications

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“…Here, we found that mice exposed to a low dose of VPA in late gestation did not cause embryonic death, or obvious congenital abnormalities, but did alter stimulus processing in both the novel object test and the fear conditioning paradigm, indicating that prenatal exposure to VPA causes persistent changes in response to the external environment. This is broadly in line with studies of sensory processing in ASD which report impaired sensory discrimination [55], as well as dysmodulation of sensory input and motor output [56,57].…”

Section: Behaviors Altered By a Low Dose Of Vpa In Late Gestationsupporting

confidence: 90%

A single low dose of valproic acid in late prenatal life alters postnatal behavior and glutamic acid decarboxylase levels in the mouse

Wei

Lam

et al. 2016

Behavioural Brain Research

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Rationale Rodents exposed to valproic acid (VPA) in prenatal life exhibit post-natal characteristics analogous to autism spectrum disorder (ASD). Many previous studies used relatively high doses of VPA during early pregnancy, potentially confounding interpretation because the offspring are the "survivors" of a toxic insult. Low dose or late gestation exposure has not been widely studied. Objectives We examined the behavioral sequelae of late gestation exposure to low dose VPA in the mouse. We also examined postnatal levels of glutamic acid decarboxylase (GAD65 and GAD67) as markers for GABA neurons, because GABA pathology and subsequent excitatory/inhibitory imbalance is strongly implicated in ASD. Methods Pregnant C57BL/6N mice received a single subcutaneous injection of 100 or 200 mg/kg on gestation day 17. The control group received a saline injection on the same day. The offspring were tested in a battery of behavioral tests in adolescence and adulthood. Six brain regions were harvested and GAD65 and GAD67 were measured by western blotting. Results Compared to saline-exposed controls, adult mice exposed to prenatal VPA had impaired novel object exploration and fear conditioning anomalies. GAD67 was decreased in midbrain, olfactory bulb, prefrontal cortex and increased in cerebellum, hippocampus and striatum; GAD65 was decreased in all 6 regions. ConclusionsOur results suggest that a low dose of VPA in late pregnancy has persistent effects on brain development, and in particular the GABA system, which 3 may be relevant to ASD. Further attention to the impact of gestation time and dose of exposure in VPA-induced ASD models is encouraged.

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Section: Behaviors Altered By a Low Dose Of Vpa In Late Gestationsupporting

confidence: 90%

A single low dose of valproic acid in late prenatal life alters postnatal behavior and glutamic acid decarboxylase levels in the mouse

Wei

Lam

et al. 2016

Behavioural Brain Research

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“…En concreto, en el meta-análisis de Ben-Sasson et al (2009), que recoge 14 estudios en los que se incluye población TEA desde los 7 meses a los 56 años de edad, se concluye que los estudios en los que se incluye el 80% o más de población TEA se obtienen elevados porcentajes en todas las subescalas de los instrumentos que evalúan el procesamiento sensorial, por lo que se afirma que la severidad del autismo está relacionada con la severidad de los síntomas sensoriales pero no tanto con el tipo de alteración. De hecho, en el estudio llevado a cabo por Papavasiliou, Nikaina, Rizou y Alexandrou (2011), en el que se realizó un programa de intervención que incluía terapia de integración sensorial, después del tratamiento se obtuvo un decremento significativo en cuanto al grado de severidad de la sintomatología, mientras que no hubo diferencias estadísticamente significativas entre el pretest y el postest en cuanto a las puntuaciones totales del procesamiento sensorial.…”

Section: Mentos De Evaluación Estandarizados Como El Sensory Integraunclassified

“…Estos investigadores concluyen que a medida que aumenta la edad se produce una disminución de las alteraciones en el procesamiento sensorial. En esta misma línea, tanto en el meta-análisis de Ben-Sasson et al (2009), como en la investigación llevada a cabo por Kern et al (2006), se ha obtenido que las alteraciones en la percepción sensorial correlacionan con la edad, de manera que estas son más elevadas en la etapa infantil y, más concretamente entre los 6 y los 9 años, mientras que se produce un descenso con posterioridad.…”

Section: Mentos De Evaluación Estandarizados Como El Sensory Integraunclassified

Relación Entre El Procesamiento Sensorial Y La Severidad De La Sintomatología en Una Muestra De Niños Con Tea

Sanz‐Cervera

Andrés

Cerezuela

et al. 2016

Revista INFAD de Psicología

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The new DSM-5 criteria include the alterations of sensory perception as a new diagnostic criterion to consider in the ASD population. Considering the inclusion of this new approach, the purpose of this study is to compare the features of sensory processing among a group of children (from 5 to 8 years old) with and without ASD. In addition to this, in the case of the ASD group, possible relationships between the sensory processing and the severity of symptoms, assessed by the GARS-2, are analyzed. To do this, the parents of 84 children (41 with ASD diagnosis and 43 with typical development), reported their perception about their children's sensory processing. The results show significant differences between both groups in all subscales assessing sensory processing. Besides this, in the case of the ASD group, sensory processing characteristics are significantly related to the severity of autistic symptoms. These results show that children with ASD have a different sensory processing to children without ASD. The evaluation of the sensory profile of this particular population should be a prerequisite, since it would allow a better understanding of the disorder and it would also provide the possibility to implement therapeutic measures tailored to the particular needs of each individual.

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“…SIRS may be considered one construct within a group of abnormal sensory response patterns Baranek, Little, Parham, Ausderau, & Sabatos-DeVito, 2014;Ben-Sasson et al, 2009;Dunn, 2001;Lane et al, 2013;Miller et al, 2007), which also include hyperresponsiveness (i.e., an overreaction to stimuli, such as being bothered by everyday sounds) and hyporesponsiveness (i.e., an underreaction to stimuli, such as having a diminished response to pain; Ausderau et al, 2014;Baranek et al, 2014;Dunn, 2001). These types of unusual sensory responses are highly prevalent among children with ASD Ben-Sasson et al, 2009;Leekam, Nieto, Libby, Wing, & Gould, 2007) and were recently added as an aspect of the diagnostic classification of ASD by the American Psychiatric Association (2013).…”

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confidence: 99%

“…These types of unusual sensory responses are highly prevalent among children with ASD Ben-Sasson et al, 2009;Leekam, Nieto, Libby, Wing, & Gould, 2007) and were recently added as an aspect of the diagnostic classification of ASD by the American Psychiatric Association (2013).…”

mentioning

confidence: 99%

Observational Characterization of Sensory Interests, Repetitions, and Seeking Behaviors

Kirby

Little

Schultz

et al. 2015

The American Journal of Occupational Therapy

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Sensory interests, repetitions, and seeking behaviors (SIRS) are common among children with autism spectrum disorder (ASD) and other developmental disabilities (DD) and involve unusual actions that intensify or reinforce a sensory experience. Researchers and practitioners typically use parent-report measures or informal clinical observations to understand the presence and nature of SIRS. In this study, we used a scoring supplement to the Sensory Processing Assessment for Young Children, an observational measure, to characterize SIRS across three groups of children—those with ASD (n = 40), DD (n = 37), and typical development (n = 39). Group differences were identified in frequency and intensity of overall SIRS, complexity of SIRS, and incidence of particular types of SIRS (i.e., posturing, sighting, proprioceptive seeking, spinning). Facial affect was also explored and found to be primarily neutral during engagement in SIRS across groups. Implications for practice and future research are discussed.

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A Meta-Analysis of Sensory Modulation Symptoms in Individuals with Autism Spectrum Disorders

Cited by 807 publications

References 23 publications

A single low dose of valproic acid in late prenatal life alters postnatal behavior and glutamic acid decarboxylase levels in the mouse

A single low dose of valproic acid in late prenatal life alters postnatal behavior and glutamic acid decarboxylase levels in the mouse

Relación Entre El Procesamiento Sensorial Y La Severidad De La Sintomatología en Una Muestra De Niños Con Tea

Observational Characterization of Sensory Interests, Repetitions, and Seeking Behaviors

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