A meta-analysis of the association of glutathione S-transferase P1 gene polymorphism with the susceptibility of breast cancer

Abstract

Glutathione S-transferase P1 (GSTP1) is one of the important mutant sites for the cancer risk at present. The conclusions of the published reports on the relationship between GSTP1 A/G gene polymorphism and the risk of breast cancer are still debated. This meta-analysis was performed to evaluate the association between GSTP1 and the risk of breast cancer. The association reports were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method. 35 investigations were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and breast cancer susceptibility, consisting of 40,347 subjects (18,665 patients with breast cancer and 21,682 controls). The association between GSTP1 A/G gene polymorphism and breast cancer risk was not found for overall population, Caucasians and Africans. Interestingly, the GSTP1 A/G gene polymorphism was associated with the susceptibility of breast cancer in Asians (G allele: OR = 1.10, 95 % CI: 1.04-1.17, P = 0.001; GG genotype: OR = 1.36, 95 % CI: 1.14-1.62, P = 0.0008; AA genotype: OR = 0.92, 95 % CI: 0.85-0.98, P = 0.02). Furthermore, the GSTP1 A/G gene polymorphism was associated with the susceptibility of breast cancer for the analysis of the controls from hospital. In conclusion, GSTP1 A/G gene polymorphism is associated with the breast cancer susceptibility in Asians. However, more studies on the relationship between GSTP1 A/G gene polymorphism and the risk of breast cancer should be performed in further.

Genetic polymorphisms and haplotype of hormone-related genes are associated with the risk of breast cancer in Chinese women

“…Zhang et al (2011) reported that the minor allele homozygotes of rs1695 (GG) were associated with an increased risk of developing BC, which is consistent with three other studies in Chinese women (Chang et al, 2006;Lee et al, 2008;Sakoda et al, 2008). Liu et al (2013) found that GSTP1 rs1695 was associated with BC risk in an Asian population, but not in Caucasians or Africans. In our data, the SNP in rs1695 was found to be associated with an increased BC risk among heterozygote carriers, which is similar to the results of Zhang et al (2011).…”

“…Reding et al (2009) showed that the GSTP1 rs1695 A allele was a protective factor for BC compared with the G allele, but several other studies found no association between rs1695 and BC risk (Ramalhinho et al, 2011;Liu et al, 2013). Zhang et al (2011) reported that the minor allele homozygotes of rs1695 (GG) were associated with an increased risk of developing BC, which is consistent with three other studies in Chinese women (Chang et al, 2006;Lee et al, 2008;Sakoda et al, 2008).…”

Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis

“…Our results provide greater confidence because of the larger number of studies included than that in previous relative meta-analyses (Liu et al, 2013). However, some limitations must be taken into consideration.…”

“…Hereditary factors including high-and moderate-penetrance genes have been identified in only about 20% of the total cases of BC (Stratton and Rahman, 2008); that is, most cases of BC are closely bound with common mutations in low penetrance genes. Also, interactions between carcinogenic agents such as estrogen are related to BC (Lynch et al, 2008;Palacios et al, 2008;Hemel and Domchek, 2010). CEMP plays an important role in the estrogen metabolism process.…”

“…The epidemiological studies conducted so far have explored the association between GSTP1 rs1695 and breast cancer risk (Liu et al, 2013), with limited success, that is, the outcome remains uncertain. The accuracy of these results might be induced by limitations such as individual studies and sparse data, or discordance among the reported original studies.…”