Which domain of life evaluation is more important? Using a large‐scale public sample of 1888 adults from the United States (880 males, 1008 females; Mage = 53.28), we addressed this question by comparing the predictive strength of six domains of life evaluations on overall life evaluation as well as biomarkers of inflammation. Specifically, we examined individuals' self‐rated evaluations of the domains of social belonging, romantic relationships, work, subjective social status, self‐esteem and finances, and we examined biological inflammation using an index of five biomarkers of inflammation: interleukin‐6, fibrinogen, C‐reactive protein, E‐selectin and intercellular adhesion molecule 1. Adjusting for demographic variability, romantic evaluation, work evaluation, self‐esteem and financial evaluation were equally and uniquely predictive of overall life evaluation. Social belonging remained predictive but was relatively weaker in magnitude, while subjective social status was no longer a significant predictor. Conversely, only financial evaluation was significantly linked to reduced biomarkers of inflammation. The findings suggest that depending on domain‐specificity and whether well‐being is assessed via subjective or objective indicators, links between life evaluations and well‐being may show substantial nuance. In particular, financial evaluation appears to have unique links to biomarkers of inflammation even after accounting for other domains of life evaluations.