A meta-analysis of the efficacy and safety of human serum albumin treatment in patients with ascites due to cirrhosis undergoing drainage

Zheng, Yingjun; Zhuo, Shijie; Huang, Bin; Su, Song

doi:10.1016/j.asjsur.2021.05.040

Cited by 2 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, six previous meta-analyses by Bernardi [ 22 ], Kwok [ 23 ], Kütting [ 24 ], Simonetti [ 25 ], Zheng [ 26 ], and Shrestha [ 27 ], primarily evaluated the efficacy of HA infusion for the prevention of post-paracentesis circulatory dysfunction in cirrhotic patients undergoing LVP, also reported the relevant data regarding its impact on the prevention of hyponatremia after LVP. By comparison, the current meta-analysis has several strengths.…”

Section: Discussionmentioning

confidence: 99%

“…By comparison, the current meta-analysis has several strengths. First, six previous meta-analyses just included cirrhotic patients undergoing LVP [ 22 , 23 , 24 , 25 , 26 , 27 ], but the current meta-analysis included general cirrhotic patients. Second, six previous meta-analyses just explored the prevention of hyponatremia after LVP [ 22 , 23 , 24 , 25 , 26 , 27 ]; by comparison, the current meta-analysis not only explored the prevention of hyponatremia, but also the treatment of hyponatremia.…”

Section: Discussionmentioning

confidence: 99%

“…First, six previous meta-analyses just included cirrhotic patients undergoing LVP [ 22 , 23 , 24 , 25 , 26 , 27 ], but the current meta-analysis included general cirrhotic patients. Second, six previous meta-analyses just explored the prevention of hyponatremia after LVP [ 22 , 23 , 24 , 25 , 26 , 27 ]; by comparison, the current meta-analysis not only explored the prevention of hyponatremia, but also the treatment of hyponatremia. Third, six previous meta-analyses just pooled the incidence of hyponatremia after LVP [ 22 , 23 , 24 , 25 , 26 , 27 ]; by comparison, the current meta-analysis not only pooled the incidence and improvement rate of hyponatremia but also pooled the serum sodium level after treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Second, six previous meta-analyses just explored the prevention of hyponatremia after LVP [ 22 , 23 , 24 , 25 , 26 , 27 ]; by comparison, the current meta-analysis not only explored the prevention of hyponatremia, but also the treatment of hyponatremia. Third, six previous meta-analyses just pooled the incidence of hyponatremia after LVP [ 22 , 23 , 24 , 25 , 26 , 27 ]; by comparison, the current meta-analysis not only pooled the incidence and improvement rate of hyponatremia but also pooled the serum sodium level after treatment. Fourth, Bernardi’s [ 22 ], Kwok’s [ 23 ], Kütting’s [ 24 ], Zheng’s [ 26 ], Simonetti’s [ 25 ] and Shrestha’s [ 27 ] meta-analyses included 13, 7, 14, 17, 11, and 13 studies, respectively; by comparison, the current meta-analysis included 25 studies regarding the prevention of hyponatremia.…”

Section: Discussionmentioning

confidence: 99%

“…To the best of our knowledge, only several previous meta-analyses partly evaluated the role of HA infusion in the prevention of hyponatremia in liver cirrhosis after large volume paracentesis (LVP) [ 22 , 23 , 24 , 25 , 26 , 27 ], but the conclusions were heterogeneous among them. Additionally, the preventive and therapeutic effects of HA infusion on hyponatremia in general liver cirrhosis have not been systematically evaluated.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Use of Human Albumin Administration for the Prevention and Treatment of Hyponatremia in Patients with Liver Cirrhosis: A Systematic Review and Meta-Analysis

Bai

Wang

Lin

et al. 2022

JCM

View full text Add to dashboard Cite

Background. Hyponatremia is a common complication of liver cirrhosis and aggravates patients’ outcomes. It may be corrected by human albumin (HA) infusion. Herein, we have conducted a systematic review and meta-analysis to evaluate the efficacy of intravenous HA administration for the prevention and treatment of hyponatremia in liver cirrhosis. Methods. Literature was searched in the PubMed, EMBASE, and Cochrane Library databases. If possible, a meta-analysis would be conducted. Incidence of hyponatremia, rate of resolution of hyponatremia, and serum sodium level were compared between cirrhotic patients who received and did not receive HA infusion. Odds ratios (ORs) or mean differences (MDs) with 95% confidence intervals (CIs) were calculated. The quality of evidence was assessed by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Results. Initially, 3231 papers were identified. Among them, 30 studies, including 25 randomized controlled trials (RCTs) and 5 cohort studies, were eligible. Among cirrhotic patients without hyponatremia, the HA infusion group had significantly lower incidence of hyponatremia (OR = 0.55, 95%CI = 0.38–0.80, p = 0.001) and higher serum sodium level (MD = 0.95, 95%CI = 0.47–1.43, p = 0.0001) as compared to the control group. Among cirrhotic patients with hyponatremia, the HA infusion group had a significantly higher rate of resolution of hyponatremia (OR = 1.50, 95%CI = 1.17–1.92, p = 0.001) as compared to the control group. Generally, the quality of available evidence is low. Conclusions. Based on the current evidence, HA may be considered for preventing the development of hyponatremia in liver cirrhosis, especially in those undergoing LVP, and treating hyponatremia. Well-designed studies are required to clarify the effects of HA infusion on hyponatremia in liver cirrhosis.

show abstract