A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer’s disease

Harenbrock, Jana; Holling, Heinz; Reid, Graham; Koychev, Ivan

doi:10.1016/j.bionps.2023.100068

Cited by 6 publications

(1 citation statement)

References 248 publications

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“…In the findings from HavenBrook and colleagues, it was noted that sleep plays a significant role in the process of long-term memory consolidation. This means that while we sleep, our brains organize and integrate the information we've learned throughout the day into long-term memory (Harenbrock et al, 2023). The brain is active during sleep, and effective consolidation of associative memory occurs through regular collaboration between slow oscillations and spindles during non-REM sleep (NREM).…”

Section: Results Of Respondents' Physical Activity On Memorymentioning

confidence: 99%

Memory Improvement in the Elderly Through Ghunnah Therapy

Fadhilah,

Adini Nur Bahri,

Zata Ismah

2023

penamas

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The vibrations produced by reading ghunnah have a favorable influence on a person's cognitive function, specifically in the form of memory strengthening or improvement in order to prevent senile dementia. The ability of tajweed Ghunnah is thought to have a good impact on memory. Furthermore, this capacity can help to prevent senility, which is a typical problem among the elderly. The purpose of this study was to investigate the effect of ghunnah therapy on memory. The quantitative approaches utilized in this investigation were combined with a pre-post experimental design. The Reading Span Test method was used to assess respondents' memory before and after ghunnah therapy. The goal was to demonstrate that Ghunnah's intervention variable was the only one that had an effect on memory improvement. The findings revealed that respondents' memory scores improved before and after ghunnah therapy. As a result, it is possible to conclude that ghunnah therapy has a substantial association with memory.

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Section: Results Of Respondents' Physical Activity On Memorymentioning

confidence: 99%

Memory Improvement in the Elderly Through Ghunnah Therapy

Fadhilah,

Adini Nur Bahri,

Zata Ismah

2023

penamas

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Neuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study

Melikyan,

Kawas,

Paganini‐Hill

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONWe investigated the association between sleep duration and neuropathologic changes 19 to 40 years later in oldest‐old (age 90+) participants of The 90+ Study.METHODSParticipants self‐reported sleep duration and underwent neuropathologic evaluation. We categorized sleep duration as < 7, 7 to 8 = reference, > 8 hours and dichotomized neuropathologic changes as present/absent. We estimated odds ratio (OR) and 95% confidence intervals (CI) using logistic regression.RESULTSIn 264 participants, mean age at sleep self‐report was 69 years, mean age at autopsy was 98 years, and mean interval between sleep self‐report and autopsy was 29 years (range: 19–40). Those reporting > 8 hours of sleep had lower likelihood of limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change (LATE‐NC) inclusions (OR = 0.18; CI = 0.04–0.82) and amyloid beta deposits (OR = 0.34; 95% CI = 0.12–0.94).DISCUSSIONLong self‐reported sleep is associated with lower odds of neurodegenerative neuropathologic changes 19 to 40 years later in the oldest‐old, suggesting a potential role of sleep in accumulation of dementia‐related neuropathologies.Highlights Association of self‐reported sleep with non‐Alzheimer's disease neuropathologic changes has not been explored. Whether sleep duration is related to dementia neuropathologic changes decades later is unclear. Long self‐reported sleep is associated with lower odds of Alzheimer's disease neuropathologic change 19 to 40 years later in the oldest‐old. Long self‐reported sleep is associated with lower odds of limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change 19 to 40 years later in the oldest‐old.

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Current and Emerging Sleep Interventions for Older Adults with or without Mild Cognitive Impairment

Suraev,

Kong,

Menczel Schrire

et al. 2024

Curr Treat Options Neurol

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Purpose of Review This systematic scoping review examines evidence from the last five years on sleep interventions in cognitive healthy older adults and those with mild cognitive impairment. Recent Findings Sleep disturbance has been identified as a potential early, modifiable risk factor for dementia, making it crucial to investigate if these interventions also enhance cognitive function and neurodegenerative biomarkers. Summary Since 2019, research on sleep interventions in older adults with or without cognitive impairment has gradually expanded, especially on non-pharmacological treatments including CBT-I, exercise, and multi-modal interventions, which show promise but require further study to confirm cognitive benefits. Pharmacological interventions have primarily focused on melatonin and orexin antagonists, with long-term safety remaining a concern. Tailored, clinically effective interventions that consider the presence of Alzheimer’s disease biomarkers, such as amyloid, tau, cerebrovascular disease, or alpha-synuclein in key sleep-related circuits, are essential to developing feasible, cost-effective, and scalable treatments for older adults with or without cognitive impairment.

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A meta-analysis of the relationship between sleep and β-Amyloid biomarkers in Alzheimer’s disease

Cited by 6 publications

References 248 publications

Memory Improvement in the Elderly Through Ghunnah Therapy

Memory Improvement in the Elderly Through Ghunnah Therapy

Neuropathologic changes at age 90+ related to sleep duration 19 to 40 years earlier: The 90+ Study

Current and Emerging Sleep Interventions for Older Adults with or without Mild Cognitive Impairment

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