A meta-analysis of the risk of boys with isolated cryptorchidism developing testicular cancer in later life

Abstract

Boys with isolated cryptorchidism are three times more likely to develop testicular cancer. The limitations of this study must be acknowledged, in particular, possible publication bias and the lack of high-quality evidence focusing on the risk of malignancy in boys with isolated cryptorchidism.

Characteristics of Incident Testicular Cancer in Lebanon - 1990-2015 Single Institutional Experience

“…Lebanese patients are diagnosed at 32 years of age, most commonly at an early stage with testicular lump being the most common presenting complaint followed by unspecific sensation of pain or heaviness similar to the published data (Garner et al, 2005). We attribute the increased percentage of early diagnosis to the high level of awareness and anxiety that affect young Lebanese patients upon detection of a testicular lump or pain (Saab et al, 2014).Similarly to our experience, cryptorchidism is the most established risk factor for testicular cancer occurring in 5-10% of patients (Ferguson and Agoulnik, 2013;Lip et al, 2013Lip et al, , p. 2013. Pathologic stratification of the testicular tumors showed that NST were almost twice more prevalent than the seminomatous subtype and that almost two-thirds of the NST were mixed germ cell tumors.…”

Age at Surgery and Outcomes of an Undescended Testis

“…6 In addition, it has been shown that UDT inhibits the differentiation of primitive germ cells, starting at 4 to 12 months, which is crucial for the production of germ cells that subsequently enable spermatogenesis. 7 Delayed repositioning of an undescended testis may result in a reduction in germ cell development and low testicular volume, potentially diminishing subsequent fertility.…”

Disorders of sex development: advances in genetic diagnosis and challenges in management

“…[71][72][73][74] An abdominal or inguinal position of the gonads represents an additional risk factor. 75 The informed decision of the parent/patient for performing gonadectomy is based on the GCC risk and the sex of rearing. 76 In boys with partial gonadal dysgenesis, Leydig cell function may be sufficient for spontaneous pubertal development [77][78][79] and, therefore, the current practice is to leave the gonads in place.…”