A meta-analysis of TP53 codon 72 polymorphism and lung cancer risk: Evidence from 15,857 subjects

P53 Arg72Pro and MDM2 SNP309 Polymorphisms Cooperate to Increase Lung Adenocarcinoma Risk in Chinese Female Non-smokers: A Case Control Study

“…The allele frequencies of p53 Pro and MDM2 G were 0.485 and 0.419, respectively, among healthy control subjects in this study; these values are similar to those of other studies on Chinese populations (0.38-0.52 and 0.42-0.52, respectively) (Hu et al, 2006;Zhang et al, 2006;Chua et al, 2010;Liu et al, 2013). Li et al (Li et al, 2009) reported the OR for Asians carrying Pro/Pro genotype to be 1.395 (95% CI = 1.206-1.613), which is much higher than that of Caucasians. Zhang et al (2006) found that smoking modified the association between the p53 Arg72Pro polymorphism and lung cancer; in contrast, both Piao et al (2011) andSakiyama et al (2005) found that it did not.…”

TP53 Gene Polymorphisms in Cancer Risk: The Modulating Effect of Ageing, Ethnicity and TP53 Somatic Abnormalities

“…Interestingly, an age-associated change in the TP53 genotype distribution was also observed for lung cancer: the elderly (60-79 yr) affected subjects were characterized by an increased frequency of TP53 major genotypes, whereas a high proportion of heterozygous genotype combinations was frequently detected in mature (40-59 yr) patients Gervas et al, 2007). These data not only agreed with recent meta-analyses (Dai et al, 2009;Francisco et al, 2010;Li et al, 2009;Yan et al, 2009) but also suggest that age might be an important modifier of the association between TP53 rs1042522 polymorphism and lung cancer risk. With regard to rs17878362 and rs1625895 germline variations, the alteration in frequency of their genotypes is most likely linked to the regulation of TP53 gene dosage particularly that which results in an increase in expression of the rs1042522 G allele, as already mentioned previously.…”

“…However, in spite of the present disagreements and methodological flaws, association tendencies for some cancer localizations are clear (Table 2). Simply stated, the rs1042522 C allele is associated with increased susceptibility to cancers, including of the lung (Dai et al, 2009;Francisco et al, 2010;Li et al, 2009;Yan et al, 2009), head and neck (Francisco et al, 2010), thyroid (Francisco et al, 2010), esophagus Zhao et al, 2010), pancreas , liver Francisco et al, 2010), gallbladder , nasopharynx (Zhuo et al, 2009b), and cervix (Francisco et al, 2010;Klug et al, 2009). No significant contribution of TP53 rs1042522 polymorphism to oral cancer has been reported (Zhuo et al, 2009c).…”

“…Lung, head and neck, thyroid C↑ no - (Dai et al, 2009;Francisco et al, 2010;Hu et al, 2010a;Li et al, 2009;Truong et al, 2010;Yan et al, 2009) (Francisco et al, 2010) ↑allele increases cancer risk. ↓allele decreases cancer risk.…”

Decreased risk of developing lung cancer in subjects carrying the CLPTM1L rs401681 (G>A) polymorphism: evidence from a meta-analysis

“…Finally, gene-gene and gene-environment interactions were not fully addressed in our meta-analysis owing to lack of sufficient data. Previous studies have demonstrated that interactions among smoking and some genetic polymorphisms were associated with lung cancer risk (Herbst et al, 2008;Li et al, 2009). Further studies are expected to explore potential gene-gene and gene-environment interactions.…”