2022
DOI: 10.3389/fphar.2022.796329
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A Meta-Analysis of Using Protamine for Reducing the Risk of Hemorrhage During Carotid Recanalization: Direct Comparisons of Post-operative Complications

Abstract: Background: Protamine can decrease the risk of hemorrhage during carotid recanalization. However, it may cause severe side effects. There is no consensus on the safety and efficacy of protamine during surgery. Thus, we conduct a comprehensive review and meta-analysis to compare the differences between the protamine and the no-protamine group.Method: We systematically obtained literature from Medline, Google Scholar, Cochrane Library, and PubMed electronic databases. All four databases were scanned from 1937 wh… Show more

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Cited by 2 publications
(2 citation statements)
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“…As a result of this analysis, we have changed our strategy back to a mandatory reversal while we continue to discuss the correct protamine dose for each case individually after termination of the extracorporeal circulation. Recent studies of other endovascular procedures, particularly percutaneous coronary intervention [11][12][13], transcatheter aortic valve replacement [14], and carotid recanalization [15,16], revealed beneficial effects of protamine for heparin reversal and only low complication rates. However, protamine may cause complex interactions in the coagulation system, including procoagulatory effects, which are not fully explored yet [17,18].…”
Section: Discussionmentioning
confidence: 99%
“…As a result of this analysis, we have changed our strategy back to a mandatory reversal while we continue to discuss the correct protamine dose for each case individually after termination of the extracorporeal circulation. Recent studies of other endovascular procedures, particularly percutaneous coronary intervention [11][12][13], transcatheter aortic valve replacement [14], and carotid recanalization [15,16], revealed beneficial effects of protamine for heparin reversal and only low complication rates. However, protamine may cause complex interactions in the coagulation system, including procoagulatory effects, which are not fully explored yet [17,18].…”
Section: Discussionmentioning
confidence: 99%
“…One meta-analysis validated the use of protamine sulfate for reducing the risk of hemorrhage after carotid recanalization. 44 However, there is little data validating its efficacy in treating ICH. A retrospective study analyzing 18 patients, 14 of whom were actively bleeding, determined that protamine is capable of partially reversing anti-Xa medications.…”
Section: Reversal Of Direct Oral Anticoagulation Agentsmentioning
confidence: 99%