A Meta-analysis of Zinc Salts Lozenges and the Common Cold

Jackson, Jeffrey L.

doi:10.1001/archinte.1997.00440410105012

Cited by 65 publications

(30 citation statements)

References 27 publications

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“…These studies appear to have addressed many of the criticisms of previous studies of the effect of zinc on common-cold symptoms [15,16]. Although the placebo treatment was not matched in this study, the responses of the volunteers suggest that the at California Institute of Technology on June 22, 2015 http://cid.oxfordjournals.org/ Downloaded from study was adequately blinded and that neither unpalatable taste nor the occurrence of adverse events should have affected the results of the study.…”

Section: Discussionmentioning

confidence: 67%

Effect of Treatment with Zinc Gluconate or Zinc Acetate on Experimental and Natural Colds

Turner

Cetnarowski²

2000

Clinical Infectious Diseases

117

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Two clinical trials were conducted, one involving 273 subjects with experimental rhinovirus colds and the other involving 281 subjects with natural colds. Symptomatic volunteers were randomized to receive oral lozenges containing zinc gluconate (13.3 mg), zinc acetate (5 or 11.5 mg), or placebo. The median duration of illness in zinc gluconate recipients was 2.5 days, contrasted with 3.5 days in the placebo recipients (P=.035), in the experimental colds study. Zinc gluconate had no effect on symptom severity and zinc acetate had no effect on either duration or severity. Neither formulation had an effect on the duration or severity of natural cold symptoms. Evaluation of blinding, taste, and adverse events revealed no significant differences among the 4 treatment arms. Zinc compounds appear to have little utility for common-cold treatment.

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Section: Discussionmentioning

confidence: 67%

Effect of Treatment with Zinc Gluconate or Zinc Acetate on Experimental and Natural Colds

Turner

Cetnarowski²

2000

Clinical Infectious Diseases

117

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“…[26][27][28] The ingestion of coins by psychiatric patients also has been reported as a source of increased zinc ingestion (leached from the coins) and subsequent copper deficiency. 25,29,30 Since 1982, pennies have been composed of 97.6% zinc and 2.4% copper; other US coins do not contain zinc.…”

Section: Discussionmentioning

confidence: 99%

Zinc-Induced Copper Deficiency

Willis¹,

Monaghan²,

Miller³

et al. 2005

Am J Clin Pathol

212

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Copper deficiency is a rare cause of sideroblastic anemia and neutropenia that often is not suspected clinically. The morphologic findings in bone marrow, while not pathognomonic, are sufficiently characteristic to suggest the diagnosis, leading to further testing to establish the correct diagnosis. Excess zinc ingestion is among the causes of copper deficiency. We present 3 cases of zinc-induced copper deficiency in which the diagnosis first was suggested on the basis of bone marrow examination. The first patient was a 47-year-old man with a debilitating peripheral neuropathy that had progressed during the previous 18 months, mild anemia, and severe neutropenia. The second was a 21-year-old man receiving zinc supplementation for acrodermatitis enteropathica in whom moderate normocytic anemia and neutropenia developed. The third patient was a 42-year-old man with anemia, severe neutropenia, and a peripheral neuropathy that had progressed during 8 months. The bone marrow findings in all cases suggested copper deficiency, which was confirmed by further laboratory testing and determined to be due to zinc excess. The morphologic features, clinical manifestations, differential diagnosis, and pathogenetic mechanisms are discussed.

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“…Using the outcome of cold symptoms after 7 days, a meta-analysis of eight clinical trials of zinc salt lozenge for the treatment of common cold did not find a significant benefit. 34 In contrast, clinical trials showed that zinc effectively and significantly shortened the duration of the common cold when it was administered within 24 h of the onset of symptoms. 35 Vitamin C may have a small role in preventing the common cold, especially in persons exposed to brief periods of severe physical activity or cold environments, 36 37 but has no apparent effect on the duration or severity of symptoms.…”

Section: Mucolytic Agentsmentioning

confidence: 99%

Acute rhinosinusitis in adults: an update on current management

Masood

Moumoulidis

Panesar

2007

Postgraduate Medical Journal

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Acute rhinosinusitis is a common disease with worldwide prevalence. It is a significant burden on the health services. It is most commonly caused by viruses and is self-limiting in nature. The diagnosis of acute rhinosinusitis is clinical and sinus radiography is not indicated routinely. Most cases of acute rhinosinusitis are treated symptomatically. However, symptoms may persist beyond 10 days when secondary bacterial infection prevails. Antibiotics are reserved for moderate or severe cases or when there is development of complications of acute rhinosinusitis. This paper provides an update on the current management of acute rhinosinusitis.

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A Meta-analysis of Zinc Salts Lozenges and the Common Cold

Abstract: Despite numerous randomized trials, the evidence for effectiveness of zinc salts lozenges in reducing the duration of common colds is still lacking.

Cited by 65 publications

References 27 publications

Effect of Treatment with Zinc Gluconate or Zinc Acetate on Experimental and Natural Colds

Effect of Treatment with Zinc Gluconate or Zinc Acetate on Experimental and Natural Colds

Zinc-Induced Copper Deficiency

Acute rhinosinusitis in adults: an update on current management

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