A meta-analysis on efficacy and safety of rituximab for neuromyelitis optica spectrum disorders

Dong, Gu-Yi; Meng, Yan; Xiao, Xueshan

doi:10.1097/md.0000000000030347

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Rituximab is a chimeric monoclonal antibody that binds to and depletes CD20-positive B-cells. Its clinical effectiveness in NMOSD has been demonstrated in various retrospective and prospective studies, including AQP4-IgG-positive and -negative (adult and pediatric) patients, with a reduction of attack rates by over 80% [ 52 , 53 , 61 , 74 , 135 , 253 ]. A recent randomized, double-blinded, placebo-controlled trial from Japan (RIN-1) confirmed the efficacy of rituximab in AQP4-IgG-positive NMOSD, although the sample size of the trial was small (Table 2 ) ([ 216 ].…”

Section: Treatment Of Nmosd: General Aspects and Outcome Measuresmentioning

confidence: 99%

Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management

Kuempfel¹,

Giglhuber²,

Aktaş³

et al. 2023

J Neurol

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This manuscript presents practical recommendations for managing acute attacks and implementing preventive immunotherapies for neuromyelitis optica spectrum disorders (NMOSD), a rare autoimmune disease that causes severe inflammation in the central nervous system (CNS), primarily affecting the optic nerves, spinal cord, and brainstem. The pillars of NMOSD therapy are attack treatment and attack prevention to minimize the accrual of neurological disability. Aquaporin-4 immunoglobulin G antibodies (AQP4-IgG) are a diagnostic marker of the disease and play a significant role in its pathogenicity. Recent advances in understanding NMOSD have led to the development of new therapies and the completion of randomized controlled trials. Four preventive immunotherapies have now been approved for AQP4-IgG-positive NMOSD in many regions of the world: eculizumab, ravulizumab - most recently-, inebilizumab, and satralizumab. These new drugs may potentially substitute rituximab and classical immunosuppressive therapies, which were as yet the mainstay of treatment for both, AQP4-IgG-positive and -negative NMOSD. Here, the Neuromyelitis Optica Study Group (NEMOS) provides an overview of the current state of knowledge on NMOSD treatments and offers statements and practical recommendations on the therapy management and use of all available immunotherapies for this disease. Unmet needs and AQP4-IgG-negative NMOSD are also discussed. The recommendations were developed using a Delphi-based consensus method among the core author group and at expert discussions at NEMOS meetings.

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