A meta-analytic assessment of a Thyroglobulin marker for marbling in beef cattle

Wood, Ian; Moser, Gerhard; Burrell, Daniel L.; Mengersen, Kerrie; Hetzel, D. J. S.

doi:10.1186/1297-9686-38-5-479

Cited by 17 publications

(4 citation statements)

References 20 publications

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“…Polymorphism in the thyroglobulin gene was not associated with backfat thickness in the present data (p > 0.05) and the allele described as favorable for high marbling (Barendse et al, 2001), designated in that study as allele 1, was found in the Canchim breed at a frequency of 16.33 % (Table 1), which is not low. The polymorphism in the 5´ leader sequence of the thyroglobulin gene was associated with intramuscular fat deposition in beef cattle (Barendse et al, 2001;Gan et al, 2008;Wood et al, 2006) and Casas et al (2005) found association of this polymorphism with fat thickness in a Brahman population, but not with marbling score; however, it could not be concluded that there was a direct effect of the TG gene on that work.…”

Section: Resultsmentioning

confidence: 99%

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Association of CSSM066 and ILSTS011 microsatellite markers and thyroglobulin gene SNP with backfat in Canchim cattle

Veneroni

Meirelles

Oliveira

et al. 2012

Sci. agric. (Piracicaba, Braz.)

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Canchim, a synthetic breed of cattle derived from the Charolais and Zebu group has been used in the beef-cattle industry in Brazil as an alternative for intensifying production.One of the main concerns with this breed is its poor fat deposition and consequently, there is an effort to increase the performance for this trait. The thyroglobulin gene is located in a QTL region for fat deposition, and reports describe the influence of a polymorphism in the 5´ leader sequence of that gene on marbling and subcutaneous fat thickness. This study analyzed the association of this polymorphism in the thyroglobulin gene, as well as of two flanking microsatellite markers, CSSM066 and ILSTS011, with backfat thickness in 987 Canchim beef cattle. The CSSM066 and ILSTS011 microsatellite markers have a effect on fat thickness in the studied populations. However, this trait did not have association with the polymorphism of the thyroglobulin gene, which suggests that other genes of bovine chromosome 14 may be responsible for the variation in this trait.

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Section: Resultsmentioning

confidence: 99%

“…The thyroglobulin gene (TG) was mapped in this region (Threadgill et al, 1990) and it has been indicated as a candidate gene for fat deposition traits in beef cattle (Barendse et al, 2001;Gan et al, 2008;Casas et al, 2005 andWood et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Association of CSSM066 and ILSTS011 microsatellite markers and thyroglobulin gene SNP with backfat in Canchim cattle

Veneroni

Meirelles

Oliveira

et al. 2012

Sci. agric. (Piracicaba, Braz.)

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“…This result could be due to the rearing period being too short (<250 days) or other factors. Wood et al, in their meta-analysis based on 11 papers, indicated that there was a positive association between the polymorphic forms of TG5 and the degree of meat marbling [ 72 ]. A significant relationship between beef quality and TG5 for Charolaise and Angus cattle was also determined by Van Eenennaam et al [ 73 ].…”

Section: Thyroglobulinmentioning

confidence: 99%

Polymorphism of Genes and Their Impact on Beef Quality

Kostusiak

Slósarz

Gołębiewski

et al. 2023

CIMB

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The single-nucleotide polymorphism (SNP) form of genes is a valuable source of information regarding their suitability for use as specific markers of desirable traits in beef cattle breeding. For several decades, breeding work focused on improving production efficiency through optimizing the feed conversion ratio and improving daily gains and meat quality. Many research teams previously undertook research work on single-nucleotide polymorphism in myostatin (MSTN), thyroglobulin (TG), calpain (CAPN), and calpastatin (CAST) proteins. The literature review focuses on the most frequently addressed issues concerning these genes in beef cattle production and points to a number of relevant studies on the genes’ polymorphic forms. The four genes presented are worth considering during breeding work as a set of genes that can positively influence productivity and production quality.

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“…Beef industry is looking for gene markers that would identify animals that have a high propensity to accumulate intramuscular fat in order to produce tasty and tender meat 1 . To finding the candidate genes of intramuscular fat deposition, traditional QTL analysis was used based on position dependent strategy such as thyroglobulin (TG), fatty acid binding protein 4 (FABP4), or growth hormone 1 (GH1) 2 - 4 . Recently, several strategies have been developed to break the restriction of information bottleneck of the traditional candidate gene approach.…”

Section: Introductionmentioning

confidence: 99%

Identification of Candidate Genes related to Bovine Marbling using Protein-Protein Interaction Networks

Lim¹,

Kim²,

Park³

et al. 2011

Int. J. Biol. Sci.

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Complex traits are determined by the combined effects of many loci and are affected by gene networks or biological pathways. Systems biology approaches have an important role in the identification of candidate genes related to complex diseases or traits at the system level. The present study systemically analyzed genes associated with bovine marbling score and identified their relationships. The candidate nodes were obtained using MedScan text-mining tools and linked by protein-protein interaction (PPI) from the Human Protein Reference Database (HPRD). To determine key node of marbling, the degree and betweenness centrality (BC) were used. The hub nodes and biological pathways of our network are consistent with the previous reports about marbling traits, and also suggest unknown candidate genes associated with intramuscular fat. Five nodes were identified as hub genes, which was consistent with the network analysis using quantitative reverse-transcription PCR (qRT-PCR). Key nodes of the PPI network have positive roles (PPARγ, C/EBPα, and RUNX1T1) and negative roles (RXRA, CAMK2A) in the development of intramuscular fat by several adipogenesis-related pathways. This study provides genetic information for identifying candidate genes for the marbling trait in bovine.

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A meta-analytic assessment of a Thyroglobulin marker for marbling in beef cattle

Cited by 17 publications

References 20 publications

Association of CSSM066 and ILSTS011 microsatellite markers and thyroglobulin gene SNP with backfat in Canchim cattle

Association of CSSM066 and ILSTS011 microsatellite markers and thyroglobulin gene SNP with backfat in Canchim cattle

Polymorphism of Genes and Their Impact on Beef Quality

Identification of Candidate Genes related to Bovine Marbling using Protein-Protein Interaction Networks

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