A metabolic link between the urea cycle and cancer cell proliferation

Nagamani, Sandesh C.S.; Erez, Ayelet

doi:10.1080/23723556.2015.1127314

Cited by 33 publications

(28 citation statements)

References 8 publications

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“…4d). Taken together with the above results, we deduced that FATS may cause changes in the metabolic link between the urea cycle and cancer cell proliferation by reducing aspartate availability for pyrimidine synthesis 31 . To test this possibility, we next assessed the protein levels of enzymes related to aspartate-mediated pyrimidine synthesis.…”

Section: Fats Regulates Polyamine Metabolism In An Odcmediated Mannersupporting

confidence: 70%

FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer

Qiu

Wang

et al. 2020

Cell Death Dis

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Polyamine biosynthesis is an essential metabolic pathway for cell growth and differentiation in non-small-cell lung cancer (NSCLC). Fragile-site associated tumour suppressor (FATS) is a novel gene involved in cancer. The results of our previous study showed that FATS-mediated polyubiquitination of p53 promotes the activation of p53 in response to DNA damage; however, little is known about the role of FATS in metabolic reprogramming in NSCLC. In the present study, FATS was observed to be significantly downregulated in NSCLC tissues compared with paired adjacent normal tissues and was associated with the survival of NSCLC patients. We further showed that the presence of the tumour suppressor FATS in NSCLC cells led to apoptosis by inducing pro-death autophagy. In addition, FATS was shown to function as a suppressor of polyamine biosynthesis by inhibiting ornithine decarboxylase (ODC) at the protein and mRNA levels, which was partially dependent on oestrogen receptor (ER). Furthermore, FATS was observed to bind to ERβ and translocate to the cytosol, leading to ODC degradation. The findings of our study demonstrate that FATS plays important roles in polyamine metabolism in NSCLC and provides a new perspective for NSCLC progression.

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Section: Fats Regulates Polyamine Metabolism In An Odcmediated Mannersupporting

confidence: 70%

FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer

Qiu

Wang

et al. 2020

Cell Death Dis

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“…Accordingly, several reports have been published Fig. The disparity in metabolite composition between the tissues of the eye in normal state creates curiosity to understand the metabolism that drives these reactions [81] Synthesis of cyclic GMP (EC 4.6.1.2), GUACYC stating that arginosuccinate synthetase and arginosuccinase enzymes found to be differentially expressed and somatically silenced in cancer [52][53][54]. Workflow followed in the present study.…”

Section: Significant Differences Between Healthy and Cancer Modelsmentioning

confidence: 99%

“…Retina is a complex tissue with multiple cell type, whereas pigmented epithelium is a tissue with similar cell type. The disparity in metabolite composition between the tissues of the eye in normal state creates curiosity to understand the metabolism that drives these reactions [81] Synthesis of cyclic GMP (EC 4.6.1.2), GUACYC stating that arginosuccinate synthetase and arginosuccinase enzymes found to be differentially expressed and somatically silenced in cancer [52][53][54]. Furthermore, arginine deprivation and inhibition of urea cycle and arginine biosynthesis have been suggested as potential cancer treatment strategies [55,56].…”

Section: Significant Differences Between Healthy and Cancer Modelsmentioning

confidence: 99%

Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma

et al. 2018

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Retinoblastoma (RB) is a childhood eye cancer. Currently, chemotherapy, local therapy, and enucleation are the main ways in which these tumors are managed. The present work is the first study that uses constraint‐based reconstruction and analysis approaches to identify and explain RB‐specific survival strategies, which are RB tumor specific. Importantly, our model‐specific secretion profile is also found in RB1‐depleted human retinal cells in vitro and suggests that novel biomarkers involved in lipid metabolism may be important. Finally, RB‐specific synthetic lethals have been predicted as lipid and nucleoside transport proteins that can aid in novel drug target development.

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“…More than that, GART, PAICS, and ATIC, which participated in the de novo synthesis of purine, decreased significantly in shikonin-treated groups according to the result of transcriptomics analysis and PCR validation ( Figure 10). Glycinamide ribonucleotide transformylase (GART) is a significant trifunctional enzyme participating in purine and pyrimidine synthesis (Nagamani and Erez, 2016). The inhibitor of GART has been reported exerting a cytotoxic and a cytostatic effect on HCT116, MCF7, and A549 cancer cells (Bronder and Moran, 2003).…”

Section: Discussionmentioning

confidence: 99%

Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Shikonin in Colon Cancer

Chen

Gao

et al. 2020

Front. Pharmacol.

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A metabolic link between the urea cycle and cancer cell proliferation

Cited by 33 publications

References 8 publications

FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer

FATS regulates polyamine biosynthesis by promoting ODC degradation in an ERβ-dependent manner in non-small-cell lung cancer

Metabolite systems profiling identifies exploitable weaknesses in retinoblastoma

Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Shikonin in Colon Cancer

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