A metabolomics approach shows that catechin-enriched green tea attenuates ultraviolet B-induced skin metabolite alterations in mice

Jung, Eun Joo; Park, Hye Min; Lee, Jun Young; Shin, Jung Hoon; Mun, Sukyeong; Kim, Jeong Kee; Lee, Sang Jun; Liu, Kwang-Hyeon; Hwang, Jae Kwan; Lee, Choong Hwan

doi:10.1007/s11306-014-0743-x

Cited by 24 publications

(25 citation statements)

References 33 publications

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“…Gas chromatography‐time of flight (GC‐TOF)‐MS analysis was performed according to Jung et al . (), and 1 μL of derivatized samples was injected in splitless mode. Ultra‐performance LC‐quadrupole (UPLC‐Q)‐TOF‐MS analysis was processed as previously described by Suh et al .…”

Section: Methodsmentioning

confidence: 99%

Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes

Yang

Suh

Kim

et al. 2018

British J Pharmacology

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Background and PurposeThiazolidinediones, acting as PPAR‐γ ligands, reduce hepatic steatosis in humans and animals. However, the underlying mechanism of this action remains unclear. The purpose of this study was to investigate changes in hepatic metabolites and lipids in response to treatment with the thiazolidinedione pioglitazone in an animal model of obese Type 2 diabetes.Experimental ApproachMale Otsuka Long‐Evans Tokushima Fatty (OLETF) rats were orally administered either vehicle (control) or pioglitazone (30 mg·kg−1) and fed a high‐fat diet (60% kcal fat) for 12 weeks. Hepatic metabolites were analysed via metabolomic and lipidomic analyses. Gene expression and PLA2 activity were analysed in livers from pioglitazone‐treated and control rats.Key ResultsOLETF rats that received pioglitazone showed decreased fat accumulation and improvement of lipid profiles in the liver compared to control rats. Pioglitazone treatment significantly altered levels of hepatic metabolites, including free fatty acids, lysophosphatidylcholines and phosphatidylcholines, in the liver. In addition, pioglitazone significantly reduced the expression of genes involved in hepatic de novo lipogenesis and fatty acid uptake and transport, whereas genes related to fatty acid oxidation were up‐regulated. Gene expression and enzyme activity of PLA2, which hydrolyzes phosphatidylcholines to release lysophosphatidylcholines and free fatty acids, were significantly decreased in the livers of pioglitazone‐treated rats compared to control rats.Conclusions and ImplicationsOur results present evidence for the ameliorative effect of pioglitazone on hepatic steatosis, largely due to the regulation of lipid metabolism, including fatty acids, lysophosphatidylcholines, phosphatidylcholines and related gene‐expression patterns.

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Section: Methodsmentioning

confidence: 99%

Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes

Yang

Suh

Kim

et al. 2018

British J Pharmacology

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“…GC‐TOF‐MS analysis was processed as previously described by Jung et al. and 1 μL of derivatized samples was injected into the GC‐TOF‐MS instrument in splitless mode. UPLC‐Q‐TOF‐MS analysis was followed by our previous study .…”

Section: Methodsmentioning

confidence: 99%

“…Raw data processing and multivariate statistical analysis methods were previously described by Jung et al. . Significant differences and correlation coefficients were evaluated using PASW Statistics (IBM SPSS Inc., Chicago, IL, USA).…”

Section: Methodsmentioning

confidence: 99%

“…Recently, metabolomic approaches has emerged as the non‐trivial tools to correlate the particular metabolic states or biomarkers with food, medicine, or a single compound administered in animal models . Herein, we investigated the anti‐obesity effects of hyacinth bean as compared with milk thistle administration in HFD‐fed obese mice through correlating their physiological and clinical parameters with serum and liver metabolomes.…”

Section: Introductionmentioning

confidence: 99%

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In vivo metabolomic interpretation of the anti‐obesity effects of hyacinth bean (Dolichos lablab L.) administration in high‐fat diet mice

Suh

Lee

Jung

et al. 2017

Molecular Nutrition Food Res

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“…For exemple, the gallic acid has antihyperglicaemic, anti-tumoral, anti-microbial, cardio protective and neuroprotective activities [13][14][15][16][17]. (+)-Catechin has implications in cardiovascular diseases, diabetes and it protects the skin against UVB radiation [18][19][20]. The syringic acid has antibacterial, anti-steatotic, anti-inflammatory and neuroprotective properties [21][22][23], the cinnamic acid has anti-tumoral properties and it has been proven that it improves the vascular function [24][25].…”

Section: Introductionmentioning

confidence: 99%

Identification and Quantification of Phenolic Compounds from Red Currant (Ribes rubrum L.) and Raspberries (Rubus idaeus L.)

Frum

Georgescu

Gligor

et al. 2017

IJPPE

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Abstract. The extracts obtained from two types of berries: red currant and raspberries, were evaluated for their phenolic content. They were identified and quantified by using an optimized HPLC method. During the analyze several phenolic compounds were found, like: gallic acid, (+)-catechin, syringic acid, cinnamic acid, chlorogenic acid, ferulic acid, rutin and quercetin. The total amount of phenolic compounds analyzed found in red currant was greater than the one found in raspberries, due to the low variety of phenolic compounds extracted. The greatest amount of gallic acid, (+)-catechin, syringic acid, cinnamic acid, chlorogenic acid, ferulic acid and rutin was determined from the extraction of red currant berries and the raspberries extract contained the greatest source of quercetin. This study shows that red currant can provide the highest and most varied content of phenolic compounds from the analyzed berries.

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A metabolomics approach shows that catechin-enriched green tea attenuates ultraviolet B-induced skin metabolite alterations in mice

Cited by 24 publications

References 33 publications

Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes

Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes

In vivo metabolomic interpretation of the anti‐obesity effects of hyacinth bean (Dolichos lablab L.) administration in high‐fat diet mice

Identification and Quantification of Phenolic Compounds from Red Currant (<i>Ribes</i> <i>rubrum</i> L.) and Raspberries (<i>Rubus</i> <i>idaeus</i> L.)

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