A metabolomics study of Qianliexin capsule treatment of benign prostatic hyperplasia induced by testosterone propionate in the rat model

Zang, Linghe; Zhang, Yuwei; Zhao, Jing; Yuan, Yunxia; Wen, Yi; Lian, Jiaxin; Chen, Shuailong; Chen, Yiran; Liu, Weiyi; Niu, Ze; Wang, Xinyue; Peng, Chunlin; Zhang, Wenxin; Meng, Zhaoqing; Lu, Jincai

doi:10.1016/j.ab.2021.114258

Cited by 4 publications

(1 citation statement)

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“…The downstream pathways of prostate cancer signaling pathways include apoptosis signaling pathways. Chen et al [14] and Zhang et al [15] used androgen blockade to treat prostate cancer patients and rats, respectively, and found that it can lead to osteoporosis in prostate cancer patients and rats. However, the specific mechanism of action is still unclear.…”

Section: Resultsmentioning

confidence: 99%

Network-Based Pharmacology to Explore the Role of Drynaria fortune in Combination with Platelet-Rich Plasma Intervention for Fracture Healing Disorders

Rong,

Liu,

Yang

et al. 2024

IJPS

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Rong et al.: To Explore the Role of Drynaria fortunei with Platelet-Rich Plasma InterventionBased on network pharmacology and molecular docking techniques and methods, to explore the active components and potential effects of Drynaria fortunei combined with platelet-rich plasma intervention therapy on fracture healing diseases. The gene cards database, the human Mendelian genetic database, Online Mendelian Inheritance in Man database, and the DisGeNET database were searched to identify fracture-related targets. Then, the active chemical components and targets in Rhizoma Drynariae were screened through the traditional Chinese medicine systematic pharmacology and analysis platform database. Then, the characteristic genes of platelet-rich plasma were searched through the GSE203196, and the common targets of drugs and diseases were screened through R language. Construct a drug candidate compound target network diagram. Use the protein interaction network function enrichment analysis database and the Cytoscape software to build a protein interaction network, use AutoDock Vina for analysis and docking, use R language to conduct Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis on the critical targets of the fracture of the combination of Drynaria fortunei and platelet-rich plasma intervention therapy, and determine the core target and mechanism of the variety of Drynaria fortunei and platelet-rich plasma treatment of the fracture. A total of 18 active compounds were obtained from Rhizoma Drynariae. There are 18 overlapping targets of Drynaria and platelet-rich plasma fracture. There are 13 active ingredients related to disease targets. Rhizoma Drynariae and plateletrich plasma are mainly involved in regulating prostaglandin-endoperoxide synthase 2, androgen receptor, caspase-2, and B-cell lymphoma 2 to play a role in treating fractures. The treatment of fracture with Drynaria fortunei combined with platelet-rich plasma is a complex process of multicomponents, multi-targets, and multi-pathways related to the coordinated regulation of multiple targets and signal pathways.

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Section: Resultsmentioning

confidence: 99%