A metagenome-wide association study of gut microbiome and visceral fat accumulation

Nie, Xiaomin; Chen, Jiarui; Ma, Xiaojing; Ni, Yueqiong; Shen, Yun; Yu, Haoyong; Panagiotou, Gianni; Bao, Yuqian

doi:10.1016/j.csbj.2020.09.026

Cited by 46 publications

(37 citation statements)

References 73 publications

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“…Few studies have explored the relationships between gut microbiota and visceral fat. Nie et al (2020) found that members of the families Clostridiales and Lachnospiraceae were strongly negatively correlated with obesity parameters such as WC, VFA, TG, LDL, HbA1c, SBP, and DBP. Most of these correlations were negative, which supports the findings of our analysis.…”

Section: Discussionmentioning

confidence: 93%

“…These changes resulted from an increase in SCFA-producing species, which increased the level of SCFAs and upregulated SCFA-GLP1/PYY-associated sensory mediators. C. citroniae was also enriched in the healthy group compared with the obese cohort (Nie et al, 2020). In addition, C. scindens has been shown to inhibit Clostridium difficile infection by producing secondary bile acids that enhance resistance to C. difficile colonization (Mills et al, 2018).…”

Section: Discussionmentioning

confidence: 98%

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A Metagenome-Wide Association Study of the Gut Microbiome and Metabolic Syndrome

Qin

Yang

et al. 2021

Front. Microbiol.

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Metabolic syndrome (MetS) is a wide-ranging disorder, which includes insulin resistance, altered glucose and lipid metabolism, and increased blood pressure and visceral obesity. MetS symptoms combine to result in a significant increase in cardiovascular risk. It is therefore critical to treat MetS in the early stages of the disorder. In this study, 123 MetS patients and 304 controls were recruited to determine whether the gut microbiome plays a role in MetS development and progression. By using whole-genome shotgun sequencing, we found that the gut microbiomes of MetS patients were different from those of controls, with MetS patients possessing significantly lower gut microbiome diversity. In addition, 28 bacterial species were negatively correlated with waist circumstance, with Alistipes onderdonkii showing the strongest correlation, followed by Bacteroides thetaiotaomicron, Clostridium asparagiforme, Clostridium citroniae, Clostridium scindens, and Roseburia intestinalis. These species were also enriched in controls relative to MetS patients. In addition, pathways involved in the biosynthesis of carbohydrates, fatty acids, and lipids were enriched in the MetS group, indicating that microbial functions related to fermentation may play a role in MetS. We also found that microbiome changes in MetS patients may aggravate inflammation and contribute to MetS diseases by inhibiting the production of short-chain fatty acids (SCFAs). Taken together, these results indicate the potential utility of beneficial gut microbiota as a potential therapeutic to alleviate MetS.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 98%

A Metagenome-Wide Association Study of the Gut Microbiome and Metabolic Syndrome

Qin

Yang

et al. 2021

Front. Microbiol.

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“…Recent studies underline the connection between visceral fat mass and the gut microbiota 6 , 7 . We show here for the first time the link between gut microbiota changes and visceral fat mass.…”

Section: Discussionmentioning

confidence: 99%

“…Recent studies identified that gut microbiota are an important factor influencing visceral fat mass independently of diet 6 and some specific microbial metabolic pathways are associated with visceral fat 7 .This may explain the contrasting findings about the links between dietary macronutrient intake and visceral fat mass. For example, while Le Roy et al reported that increasing dietary protein intake is associated with higher visceral fat mass 6 , others have reported the opposite 8 , 9 .…”

Section: Introductionmentioning

confidence: 99%

Protein supplementation during an energy-restricted diet induces visceral fat loss and gut microbiota amino acid metabolism activation: a randomized trial

Lassen

Prifti

Dao

et al. 2021

Sci Rep

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Interactions between diet and gut microbiota are critical regulators of energy metabolism. The effects of fibre intake have been deeply studied but little is known about the impact of proteins. Here, we investigated the effects of high protein supplementation (Investigational Product, IP) in a double blind, randomised placebo-controled intervention study (NCT01755104) where 107 participants received the IP or an isocaloric normoproteic comparator (CP) alongside a mild caloric restriction. Gut microbiota profiles were explored in a patient subset (n = 53) using shotgun metagenomic sequencing. Visceral fat decreased in both groups (IP group: − 20.8 ± 23.2 cm2; CP group: − 14.5 ± 24.3 cm2) with a greater reduction (p < 0.05) with the IP supplementation in the Per Protocol population. Microbial diversity increased in individuals with a baseline low gene count (p < 0.05). The decrease in weight, fat mass and visceral fat mass significantly correlated with the increase in microbial diversity (p < 0.05). Protein supplementation had little effects on bacteria composition but major differences were seen at functional level. Protein supplementation stimulated bacterial amino acid metabolism (90% amino-acid synthesis functions enriched with IP versus 13% in CP group (p < 0.01)). Protein supplementation alongside a mild energy restriction induces visceral fat mass loss and an activation of gut microbiota amino-acid metabolism.Clinical trial registration: NCT01755104 (24/12/2012). https://clinicaltrials.gov/ct2/show/record/NCT01755104?term=NCT01755104&draw=2&rank=1.

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“…A better understanding of the microbial ecology of colonic acetate-and succinate-producing bacteria, especially the Coprococcus_2 and Prevotella groups, may help to explain the influence of diet on the acetate and succinate supply and may contribute to the development of new approaches for optimizing microbial activity for diet management for GDM subjects. Eubacterium ventriosum, another SCFAs producer, had been found negative correlated with visceral fat area (VFA) (39). Moraes et al reported that the abundance of E. ventriosum were associated to better cardiometabolic profile (40).…”

Section: Discussionmentioning

confidence: 99%

The gut microbial signature of gestational diabetes mellitus and the association with diet intervention

Zhou

et al. 2021

Preprint

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Gestational diabetes mellitus (GDM) is a high-risk pregnancy complication that is associated with metabolic disorder phenotypes, such as abnormal blood glucose and obesity. The link between microbiota and diet management contributes to metabolic homeostasis in GDM. Therefore, it is crucial to understand the structure of the gut microbiota in GDM and to explore the effect of dietary management on the microbiota structure. In this study, we analyzed the composition of the gut microbiota between 27 GDM and 30 healthy subjects at two time points using Illumina HiSeq 2500 platform. The taxonomy analyses suggested that the overall bacteria clustered by diabetes status, rather than diet intervention. Of particular interest, the phylum Acidobacteria in GDM was significantly increased, and positively correlated with blood glucose levels. Moreover, Partial least-squares discriminant analysis (PLS-DA) revealed that certain genera in the phyla Firmicutes, Bacteroidetes, Proteobacteria, and Lentisphaerae characterized the GDM gut microbiota. Correlation analysis indicated that blood glucose levels and BMI index were correlated with the relative abundance of SCFAS-producing genera. Through the comparison between the GDM and healthy samples with or without diet intervention, we discovered that the role of short-term diet management in GDM processes is associated with the change in the Firmicutes/Bacteroidetes ratio and some specific taxa, rather than an alternative gut microbial pattern. Our study have important implications for understanding the beneficial effects of diet intervention on the specific gut microbiota and thus possibly their metabolism in pregnant women with GDM.

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A metagenome-wide association study of gut microbiome and visceral fat accumulation

Abstract: Graphical abstract

Cited by 46 publications

References 73 publications

A Metagenome-Wide Association Study of the Gut Microbiome and Metabolic Syndrome

A Metagenome-Wide Association Study of the Gut Microbiome and Metabolic Syndrome

Protein supplementation during an energy-restricted diet induces visceral fat loss and gut microbiota amino acid metabolism activation: a randomized trial

The gut microbial signature of gestational diabetes mellitus and the association with diet intervention

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