A metagenomic study of patients with alveolar osteitis after tooth extraction. A preliminary case-control study

Aguilar-Duran, Laura; Figueiredo, Rui; Seminago, Ramón; Roig, Francisco J.; Lloréns, Carlos; Valmaseda‐Castellón, Eduard

doi:10.1007/s00784-019-02855-7

Cited by 12 publications

(17 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This agrees with our own observations, and has been described in epidemiological studies of dry socket as a statistical finding, though the cause of this greater predisposition remains unclear ( Table 3 ). Recent articles suggest that the presence of bacteria in the post-extraction socket may play a key role as a risk factor for dry socket ( 15 ); this in turn could justify the results obtained in our study.…”

Section: Discussionsupporting

confidence: 82%

“…In a recent study comparing the microbiota present in post-extraction alveoli with and without dry socket, only 45 of the 151 bacterial species identified were found to be common in both groups, which may suggest a bacterial role in the development of dry socket ( 15 ). The most frequently found bacteria in the sockets were: P. nanceiensis, A. odontolyticus, T. maltophilum, V. dispar, T. forsythia, L. mesenteroides , P. intermedia, P. melaninogenica, P. micra and F. nucleatum – most of these species being gramnegative.…”

Section: Discussionmentioning

confidence: 99%

“…Other factors contributing to the occurrence of dry socket are traumatic extractions, the female gender, tobacco use, oral contraceptive use and pre-existing infections ( 14 ). The latest published studies on this subject, involving the use of microbiological techniques, suggest that the presence of certain pathogens may be implicated in the origin of dry socket, since patients who develop alveolar osteitis after dental extraction present a microbiota different from that seen in patients without postoperative complications ( 15 , 16 ). In addition, it must be noted that a previous history of dry socket has been associated to the risk of developing the complication again in future dental extractions ( 17 , 18 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Previous dry socket as a risk factor for alveolar osteitis: A nested case-control study in primary healthcare services

Taberner-Vallverdú¹,

Camps‐Font²,

Gay‐Escoda³

et al. 2022

J Clin Exp Dent

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Previous dry socket as a risk factor for alveolar osteitis: A nested case-control study in primary healthcare services

Taberner-Vallverdú¹,

Camps‐Font²,

Gay‐Escoda³

et al. 2022

J Clin Exp Dent

View full text Add to dashboard Cite

“…This was similar in Box 5. Box 3 and Box 4 were characterized by periodontal health-associated taxa and other bacteria considered to have low pathogenicity, such as Prevotella nanceiensis, Lautropia mirabilis , and Prevotella melaninogenica ( Colombo et al., 2012 ; Teles et al., 2012 ; Aguilar-Durán et al., 2019 ; Ikeda et al., 2019 ; Beydoun et al., 2020 ; Papapanou et al., 2020 ). The abundance of health-related taxa was the highest in group H and the lowest in group P, and it was relatively high in group P2 among the three P groups.…”

Section: Resultsmentioning

confidence: 99%

Potential Roles of the Free Salivary Microbiome Dysbiosis in Periodontal Diseases

Diao

Yuan

Tong

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Saliva is a vital mediator in the oral cavity. The dysbiosis of free bacteria in saliva might be related to the onset, development, prognosis, and recurrence of periodontal diseases, but this potential relationship is still unclear. The objective of this study was to investigate the potential roles of the free salivary microbiome in different periodontal statuses, their reaction to nonsurgical periodontal therapy, and differences between diseased individuals after treatment and healthy persons. We recruited 15 healthy individuals, 15 individuals with gingivitis, and 15 individuals with stage I/II generalized periodontitis. A total of 90 unstimulated whole saliva samples were collected and sequenced using full-length bacterial 16S rRNA gene sequencing. We found that as the severity of disease increased, from healthy to gingivitis and periodontitis, the degree of dysbiosis also increased. A higher abundance of Prevotella intermedia and Catonella morbi and a lower abundance of Porphyromonas pasteri, Prevotella nanceiensis, and Haemophilus parainfluenzae might be biomarkers of periodontitis, with an area under curve (AUC) reaching 0.9733. When patients received supragingival scaling, there were more pathogens related to recolonization in the saliva of periodontitis patients than in healthy persons. Even after effective nonsurgical periodontal therapy, individuals with periodontitis displayed a more dysbiotic and pathogenic microbial community in their saliva than healthy individuals. Therefore, the gradual transition in the entire salivary microbial community from healthy to diseased includes a gradual shift to dysbiosis. Free salivary pathogens might play an important role in the recolonization of bacteria as well as the prognosis and recurrence of periodontal diseases.

show abstract

“…It is accompanied by a partially or totally disintegrated blood clot resulting in the exposure of the alveolar socket walls, associated with acute and intense pain, without any sign of inflammation or infection and with or without halitosis [2,3]. The incidence is estimated at between 5 and 30% [4] with a greater rate occurring after the extraction of the mandibular third molars [5]. AO is still poorly understood and different factors have been reported as being predisposing factors for the development of dry socket, relating either to the patient, such as age, gender, smoking habit, or the use of oral contraceptives, or to a traumatic surgical extraction or previous infection [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Advanced Platelet-Rich Fibrin as a Therapeutic Option in the Treatment of Dry Socket: Literature Review and Case Series

et al. 2021

View full text Add to dashboard Cite

Alveolar osteitis (AO) is one of the complications that occur after tooth extraction. The aim of this study has been to evaluate the efficacy of Advanced Platelet-rich Fibrin (A-PRF) in the management of pain and the acceleration of wound healing in the treatment of AO. Consecutive patients who were diagnosed with AO, recruited from patients referred to the Oral Surgery Department of the University of Naples Federico II, were enrolled. After local anesthesia, the dry socket was curetted and irrigated with saline. The Platelet-rich Fibrin (PRF) clot was placed in the socket and then covered with an A-PRF membrane. Clinical parameters, such as the degree of pain and rate of granulation tissue (GT) formation, were measured before treatment and after 1, 3, 7, 14, and 21 days. The Friedman test for dependent samples was used to detect the treatment and time effect. Four patients with established AO were included. On all the examination days, the post-operative recovery was uneventful. The pain scores progressively reduced, from an average of 8.5 before treatment to 0.25 on the third day, and the GT formation improved over time. The use of A-PRF in the treatment of AO significantly reduced the pain level and enhanced the wound-healing process.

show abstract

A metagenomic study of patients with alveolar osteitis after tooth extraction. A preliminary case-control study

Cited by 12 publications

References 28 publications

Previous dry socket as a risk factor for alveolar osteitis: A nested case-control study in primary healthcare services

Previous dry socket as a risk factor for alveolar osteitis: A nested case-control study in primary healthcare services

Potential Roles of the Free Salivary Microbiome Dysbiosis in Periodontal Diseases

Advanced Platelet-Rich Fibrin as a Therapeutic Option in the Treatment of Dry Socket: Literature Review and Case Series

Contact Info

Product

Resources

About