2023
DOI: 10.1101/2023.10.06.561241
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A metagenomics pipeline reveals insertion sequence-driven evolution of the microbiota

Joshua M. Kirsch,
Andrew J. Hryckowian,
Breck A. Duerkop

Abstract: Insertion sequence (IS) elements are mobile genetic elements in bacterial genomes that support adaptation. We developed a database of IS elements coupled to a computational pipeline that identifies IS element insertions in the microbiota. We discovered that diverse IS elements insert into the genomes of intestinal bacteria regardless of human host lifestyle. These insertions targeted bacterial accessory genes that aid in their adaptation to unique environmental conditions. Using IS element expansion inBacteroi… Show more

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