2014
DOI: 10.1016/j.tetlet.2014.03.094
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A metal-free cross-dehydrogenative coupling of N-carbamoyl tetrahydroisoquinoline by sodium persulfate

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Cited by 37 publications
(16 citation statements)
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“…Moreover, N ‐acyl‐derived THIQs have a poor reactivity and require the participation of strong oxidants . Very recently, benzyloxycarbonyl (Cbz) protected THIQs were coupled with a series of pronucleophiles under both solvent and solvent‐free heating (SFH) conditions . Despite the excellent performance of N ‐Cbz‐protected THIQs, tert ‐butoxycarbonyl (Boc) protected THIQs still work poorly under similar conditions, which results in large amounts of unexpected mixtures that are assumed to be the result of the harsh reaction conditions.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, N ‐acyl‐derived THIQs have a poor reactivity and require the participation of strong oxidants . Very recently, benzyloxycarbonyl (Cbz) protected THIQs were coupled with a series of pronucleophiles under both solvent and solvent‐free heating (SFH) conditions . Despite the excellent performance of N ‐Cbz‐protected THIQs, tert ‐butoxycarbonyl (Boc) protected THIQs still work poorly under similar conditions, which results in large amounts of unexpected mixtures that are assumed to be the result of the harsh reaction conditions.…”
Section: Introductionmentioning
confidence: 99%
“…In 2014, two reports from Liu, Lou, and co‐workers described CDC protocols for uniting cyclic benzylic ethers (Scheme a) or N ‐carbamoyl tetrahydroisoquinoline (Scheme b) with diverse nucleophiles including carbonyl compounds and electron‐rich arenes ,…”
Section: Conversion Of Sp3 C–h To C–c Bonds With Peroxydisulfatementioning
confidence: 99%
“…demonstrated the metal free oxidative C‐1 arylation of N ‐carbamoyl tetrahydroisoquinolines using aryl boronates . A similar reaction using sodium persulphate has been explored by Lou et.al . Walsh and coworkers described the palladium catalysed C‐1 arylation of N ‐Boc protected THIQs …”
Section: Introductionmentioning
confidence: 99%