A metal free reduction of aryl-N-nitrosamines to the corresponding hydrazines using a sustainable reductant thiourea dioxide

Abstract

Reduction of aryl-N-nitrosamines to the corresponding hydrazines is reported under metal free conditions using a sustainable industrial reductant thiourea dioxide (TDO).

An Efficient Metal‐Free Method for the Denitrosation of Aryl N‐Nitrosamines at Room Temperature

“…To the best of our knowledge organosilanes have not been explored in denitrosation reactions. In continuation of our previous works on N ‐nitrosamine chemistry, here we report an efficient method for the denitrosation of aryl‐ N ‐nitrosamines using an iodine‐triethylsilane system (Scheme ).…”

Nitrosamine Reactivity: A Survey of Reactions and Purge Processes

“…Thiourea dioxide (TDO) has been reported as the most efficient sulfurous reducing agent studied (Scheme 8). 46 It has shown the ability to reduce aryl secondary nitrosamines to the corresponding hydrazines.…”

Metal-free synthesis of gem-difluorinated heterocycles from enaminones and difluorocarbene precursors

“…65 Finally, 2H-furan could be further aromatized to highly functionalized furan in the presence of thiourea dioxide under basic conditions to afford 8 in 71% yield. 66 The insecticidal activity of the 3,3-difluoro-2H-furans against Aphis craccivora were evaluated using the spraying method (Table 3). Aphis craccivora can cause severe damage to crop yields and quality through direct attack and indirect transmission of viruses, and can cause yield losses of Z40% in soybean production.…”