2006
DOI: 10.1002/anie.200504319
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A Metal‐Ion‐Releasing Probe for DNA Detection by Catalytic Signal Amplification

Abstract: Seeing the light: Upon binding to a complementary nucleic acid, a metal‐complex–DNA conjugate releases copper(II) ions that activate the precatalyst 1,10‐phenanthroline (phen) and amplify the primary signal through catalytic production of a fluorescent dye (DCF). This combination of allosteric signal transduction and catalytic signal amplification imitates biological signaling cascades. tpy=2,2′:6′,2′′‐terpyridine.

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Cited by 57 publications
(28 citation statements)
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“…The binding of metal ions, such as Cu(I), Ag(I), Au(I), Ca(II), Mg(II), Ba(II), Sr(II), Zn(II), Cd(II), Cu(II), Co(II), Ni(II), Mn(II), Pt(II), Pd(II), Pb(II), Hg(II), La(III), Ru(III), Tb(III), Dy(III), Ce(III), Cr(III) and Al(III), to different sources of DNA was widely studied and applied to chemical analyses and polymer syntheses. [7][8][9][10][11][12][13][14][15][16] Recently, Al was shown to induce DNA damage and endoreduplication and to have clastogenic effects in human lymphocytes incubation. [17][18][19] The Al-DNA adduct was identified in clinic samples.…”
Section: Introductionmentioning
confidence: 99%
“…The binding of metal ions, such as Cu(I), Ag(I), Au(I), Ca(II), Mg(II), Ba(II), Sr(II), Zn(II), Cd(II), Cu(II), Co(II), Ni(II), Mn(II), Pt(II), Pd(II), Pb(II), Hg(II), La(III), Ru(III), Tb(III), Dy(III), Ce(III), Cr(III) and Al(III), to different sources of DNA was widely studied and applied to chemical analyses and polymer syntheses. [7][8][9][10][11][12][13][14][15][16] Recently, Al was shown to induce DNA damage and endoreduplication and to have clastogenic effects in human lymphocytes incubation. [17][18][19] The Al-DNA adduct was identified in clinic samples.…”
Section: Introductionmentioning
confidence: 99%
“…[16,[18][19][20][21][22][23][24][25][26][27][28][29][30]33] Besides this application, the use of ligand-modified DNA oligonucleotides for the sequence-specific detection of nucleic acids has also been reported. [31,34,35,37] However, the use of a ligand-based nucleoside in the generation of higher-order DNA structure was only reported by us recently. [54] A reasonable approach to using ligand-based nucleosides for the assembly of higher-order DNA structures is their incorporation at the end of an oligonucleotide.…”
Section: Metal-ion-induced Aggregation Of Bipyridinecontaining Oligonmentioning
confidence: 98%
“…For example, it should become possible to generate nucleic acids with tailored magnetic and electric properties, [15] to store and retrieve information based on the sequence of the metal complexes or their electric or photoelectric properties, [16] or to use the chirality of the DNA double helix to induce enantioselectivity in a reaction catalyzed by the incorporated metal ion. [17] One possibility to incorporate site-specifically metal ions into a nucleic acid is the covalent attachment of suitable ligands either to the oligonucleotide backbone [16,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] or to the natural nucleobases. [36][37][38][39][40] Only recently, the use of artificial metal-ion-mediated base pairs was suggested as an alternative means.…”
Section: Introductionmentioning
confidence: 99%
“…These modified nucleotides include 2′-O-methylated [7678], phosphorothioate derivatives [79, 80], peptide nucleic acids (PNA) [81, 82], and locked nucleic acids (LNA) [83]. 2′-O-methylated MBs offer good nuclease resistance and also resist RNase activity [76]; the main disadvantage for its use is the high background due to nonspecific interactions with proteins [8486], another common problem is probe accumulation at the nucleus [87] and mitochondria [88]. In order to avoid the nuclear accumulation a quantum dot (QD) has been recently linked to the 2′-O-methylated MB [89], the linker is a biotin-dT group at the 3′ stem.…”
Section: Chemistry Approaches For High Performance Molecular Beaconsmentioning
confidence: 99%