With the development of shale gas horizontal well-filling technology, by drilling infill wells between wells, the well spacing is continuously reduced to make shale reservoir reconstruction more effective. However, in shale gas reservoirs in China, the problem of inter-well interference is becoming increasingly serious, which not only affects the production of well groups but also causes wellbore damage. Currently, the process of interference in the production process is unclear. This study addresses the inter-well interference issue in deep shale gas reservoirs. An integrated numerical simulation method combining the Discrete Fracture Network, Finite Element Method, and Finite Difference Method is proposed. A comprehensive reservoir numerical model considering the production process is proposed. According to the actual reservoir model parameters and operation parameters, a multi-factor analysis model under multiple production conditions was established. Cumulative gas production and inter-well interference were analyzed. Finally, a field model was established, and the history matching of formation pressure was carried out. According to the history-matching results, the pressure expansion range in the production stage was analyzed. These research results provide a scientific basis and practical suggestions for the effective management and mitigation of inter-well interference and are expected to play an important role in practical engineering applications.