A method for direct thalamic stimulation in fMRI studies using a glass-coated carbon fiber electrode

Shyu, Bai-Chuang; Lin, Chun Nan; Sun, Jyh-Jang; Sylantyev, Sergiy; Chang, Chen

doi:10.1016/j.jneumeth.2004.02.015

Cited by 15 publications

(8 citation statements)

References 25 publications

(29 reference statements)

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“…A major step to achieve simultaneous FSCV-fMRI is ensuring that FSCV material components do not produce imaging artifacts. Traditional glass capillary microelectrodes, like those used for FSCV, produce minor artifacts ( Shyu et al, 2004 ), but polyimide-fused silica further enhances MR-compatibility ( Yang et al, 2013 ) and is also used with FSCV microelectrodes ( Fig. 2A ) ( Clark et al, 2010 ).…”

Section: Resultsmentioning

confidence: 99%

Simultaneous fMRI and fast-scan cyclic voltammetry bridges evoked oxygen and neurotransmitter dynamics across spatiotemporal scales

et al. 2021

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The vascular contributions of neurotransmitters to the hemodynamic response are gaining more attention in neuroimaging studies, as many neurotransmitters are vasomodulatory. To date, well-established electrochemical techniques that detect neurotransmission in high magnetic field environments are limited. Here, we propose an experimental setting enabling simultaneous fast-scan cyclic voltammetry (FSCV) and blood oxygenation level-dependent functional magnetic imaging (BOLD fMRI) to measure both local tissue oxygen and dopamine responses, and global BOLD changes, respectively. By using MR-compatible materials and the proposed data acquisition schemes, FSCV detected physiological analyte concentrations with high temporal resolution and spatial specificity inside of a 9.4 T MRI bore. We found that tissue oxygen and BOLD correlate strongly, and brain regions that encode dopamine amplitude differences can be identified via modeling simultaneously acquired dopamine FSCV and BOLD fMRI time-courses. This technique provides complementary neurochemical and hemodynamic information and expands the scope of studying the influence of local neurotransmitter release over the entire brain.

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Section: Resultsmentioning

confidence: 99%

Simultaneous fMRI and fast-scan cyclic voltammetry bridges evoked oxygen and neurotransmitter dynamics across spatiotemporal scales

et al. 2021

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“…The coatings are biocompatible as there is no evidence of gliosis or unusual tissue structure at the tip of the electrode where the stimulation and recordings occur. If one were to use an acute electrode implant, as has been done by Shyu et al (10), then there are increased complications related to trying to keep the electrode from moving relative to the animal during the study. The tissue will have acute trauma, including bleeding, blood brain barrier disruption, and cellular damage.…”

Section: Discussionmentioning

confidence: 99%

Functional brain mapping at 9.4T using a new MRI‐compatible electrode chronically implanted in rats

Dunn¹,

Tuor²,

Kmech³

et al. 2008

Magnetic Resonance in Med

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There is a need for acute and chronic stimulation of the brain within the MRI for studies of epilepsy, as well as deep brain stimulation for movement and behavioral disorders. This work describes the production and characteristics of carbon fiberbased electrodes for acute and chronic stimulation in the brain. Increasing MRI field strengths are making it increasingly difficult to introduce foreign objects without a susceptibility artifact. We describe the production of, and the characteristics of carbon fiber-based electrodes. These are biocompatible and can be implanted for chronic studies. We show the use of these electrodes at 9.4T for studying functional activation. Data are presented showing regional connectivity. Activation not only occurs near the electrode, but at sites distant and often contralateral to the electrode. In addition, there were sites showing strong negative activation to stimulation both with direct stimulation and during a kindling-associated seizure. Magn Reson Med 61:222-228, 2009.

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“…Using glass-coasted carbon fiber electrodes methods for direct stimulation of brain structures have been described in which the authors report little distortion of images acquired (Shyu et al, 2004b; Shyu et al, 2004a). Stimulation of the medial thalamus resulted in an increase in signal in the anterior cingulate cortex (ACC).…”

Section: Preclinical Imaging Of Pain and Analgesics In Future Resementioning

confidence: 99%

CNS animal fMRI in pain and analgesia

Borsook

Becerra

2011

Neuroscience & Biobehavioral Reviews

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Animal imaging of brain systems offers exciting opportunities to better understand the neurobiology of pain and analgesia. Overall functional studies have lagged behind human studies as a result of technical issues including the use of anesthesia. Now that many of these issues have been overcome including the possibility of imaging awake animals, there are new opportunities to study whole brain systems neurobiology of acute and chronic pain as well as analgesic effects on brain systems de novo (using pharmacological MRI) or testing in animal models of pain. Understanding brain networks in these areas may provide new insights into translational science, and use neural networks as a "language of translation" between preclinical to clinical models. In this review we evaluate the role of functional and anatomical imaging in furthering our understanding in pain and analgesia.

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A method for direct thalamic stimulation in fMRI studies using a glass-coated carbon fiber electrode

Cited by 15 publications

References 25 publications

Simultaneous fMRI and fast-scan cyclic voltammetry bridges evoked oxygen and neurotransmitter dynamics across spatiotemporal scales

Simultaneous fMRI and fast-scan cyclic voltammetry bridges evoked oxygen and neurotransmitter dynamics across spatiotemporal scales

Functional brain mapping at 9.4T using a new MRI‐compatible electrode chronically implanted in rats

CNS animal fMRI in pain and analgesia

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