Objectives: The purpose of the present work is to design a shaft subjected to twisting moment, bending moment and combined twisting and bending moment by determine the reliability of the shaft. Methods: Probabilistic approach is considered to find the lifetime of shaft by taking stress as random variable. Exponential and Weibull distributions are used to find lifetime of the equipment stress is considered as exponential and Weibull random variable. When the shaft is subjected to combined twisting and bending moment, the stress is found by using the two theories: (i) The maximum shear stress theory is used for ductile materials such as mild steel. (ii) The maximum normal stress theory is used for brittle materials such as cast iron. Findings: Reliability of the shaft is derived subjected to twisting and bending moments. The reliability is computed and compared for changing of the twisting moment, bending moment and diameter of the shaft. Novelty: To design a shaft by using reliability theory and to find reliability of the shaft by using the exponential and Weibull distribution is the novel idea. Keywords: Reliability, Weibull distribution, Shaft, Twisting moment, Bending moment, Combined twisting and bending moment, Exponential distribution, Maximum normal stress theory, Maximum shear stress theory