A method for repeated evaluation of pulmonary performance in unanesthetized, unrestrained guinea pigs and its application to detect effects of sulfuric acid mist inhalation

Wong, King-Lit; Alarie, Y.

doi:10.1016/0041-008x(82)90028-x

Cited by 102 publications

(29 citation statements)

References 25 publications

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“…The results obtained indicate that MIC induced severe airways obstruction and that recovery from the pulmonary effects of MIC is very slow-much slower than recovery following pulmonary irritation induced by sulfuric acid (18), toluene diisocyanate (TDI) (20), or smoke from wood (21). The recovery from MIC is similar to that following exposure to smoke from polyvinyl chloride (22 figure).…”

Section: Discussionsupporting

confidence: 58%

“…Secondly, animals were challenged with 10% CO2 to stimulate ventilation. Normal and abnormal responses to CO2 have been well characterized (18,19). The CO2 test enables a rapid assessment of pulmonary performance over time.…”

Section: Resultsmentioning

confidence: 99%

“…02 uptake was obtained by monitoring the difference between inlet and outlet using a double cell 02 analyzer as shown. A pressure transducer can also be attached to measure the pressure change (AP) due to each respiration, which is an indirect method to obtain VT (18). However, because of the intense airway obstruction caused by MIC, minute ventilation was obtained using the apparatus shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

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Sensory and pulmonary irritation of methyl isocyanate in mice and pulmonary irritation and possible cyanidelike effects of methyl isocyanate in guinea pigs.

Alarie¹,

Ferguson²,

Stock³

et al. 1987

Environ Health Perspect

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Methyl isocyanate (MIC) was evaluated for sensory and pulmonary irritation in mice. MIC was found to be both a potent sensory and pulmonary irritant in this species. From these results, a safe level of exposure for a period of 8 hr was estimated to be about 0.02 ppm for humans. Guinea pigs were also exposed to MIC for a single 3-hr exposure at a concentration of 37 ppm. During exposure to MIC, coughing was observed in all animals. Pulmonary function was evaluated immediately following exposure and intermittently on the next 35 days using CO2 challenges and flow-volume loops. Highly abnormal responses to CO2 were observed immediately after exposure in all animals. Six of the eight animals exposed to MIC died. In the two survivors, an apparent recovery was seen during the 5 days following exposure, but a worsening effect was observed at days 21 and 28, with a partial recovery at day 35. The data clearly demonstrated that the primary pulmonary effect of MIC was one of airways obstruction. Oxygen uptake and carbon dioxide output were also measured in the guinea pigs following exposure to MIC. No evidence of a cyanidelike effect was observed, in contrast to a severe depression of oxygen uptake following exposure to hydrogen cyanide.

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Section: Discussionsupporting

confidence: 58%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Sensory and pulmonary irritation of methyl isocyanate in mice and pulmonary irritation and possible cyanidelike effects of methyl isocyanate in guinea pigs.

Alarie¹,

Ferguson²,

Stock³

et al. 1987

Environ Health Perspect

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show abstract

“…1 jet nebulizer (Wong and Alarie, 1982) by means of an infusion pump (New England Medical Instruments Inc., Medway, MA, US). The exposure airstream (25 l/min) was subsequently led through a Vigreux column and then directed into a 20 l exposure chamber of glass and stainless steel (Clausen et al, 2003) resulting in an air exchange rate of approximately 1 min -1 .…”

Section: Generation Of Test Atmospheres and Particle Characterizationmentioning

confidence: 99%

An in vitro method for predicting inhalation toxicity of impregnation spray products

Sørli

Hansen

Nørgaard

et al. 2015

ALTEX

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“…The product was led from a glass syringe into a Pitt no. 1 jet nebulizer (Wong and Alarie, 1982) by an infusion pump (New England Medical Instruments Inc., Medway, MA, USA). In the in vitro experiments, the exposure air-stream was led through glass columns and into the 1.9-l chamber of the cf-CDS and sucked out through the baseplate.…”

Section: Generation Of Ip Aerosolsmentioning

confidence: 99%

Prediction of acute inhalation toxicity using in vitro lung surfactant inhibition

Sørli

2018

ALTEX

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A method for repeated evaluation of pulmonary performance in unanesthetized, unrestrained guinea pigs and its application to detect effects of sulfuric acid mist inhalation

Cited by 102 publications

References 25 publications

Sensory and pulmonary irritation of methyl isocyanate in mice and pulmonary irritation and possible cyanidelike effects of methyl isocyanate in guinea pigs.

Sensory and pulmonary irritation of methyl isocyanate in mice and pulmonary irritation and possible cyanidelike effects of methyl isocyanate in guinea pigs.

An in vitro method for predicting inhalation toxicity of impregnation spray products

Prediction of acute inhalation toxicity using in vitro lung surfactant inhibition

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