A method of regional cerebral blood perfusion measurement using dynamic CT with an iodinated contrast medium

Nambu, Kyojiro; Takehara, R.; Terada, Tomoaki

doi:10.1111/j.1600-0404.1996.tb00537.x

Cited by 29 publications

(20 citation statements)

References 8 publications

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“…1. A dedicated software package (CBP-study, Toshiba Medical Systems Europe, Zoetermeer, Netherlands) based on a parametric deconvolution algorithm was used for quantitation of PCT parameters [11].…”

Section: Methodsmentioning

confidence: 99%

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Dose reduction in dynamic perfusion CT of the brain: effects of the scan frequency on measurements of cerebral blood flow, cerebral blood volume, and mean transit time

et al. 2008

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The influence of the frequency of computed tomography (CT) image acquisition on the diagnostic quality of dynamic perfusion CT (PCT) studies of the brain was investigated. Eight patients with clinically suspected acute ischemia of one hemisphere underwent PCT, performed on average 3.4 h after the onset of symptoms. Sixty consecutive images per slice were obtained with individual CT images obtained at a temporal resolution of two images per second. Eight additional data sets were reconstructed with temporal resolutions ranging from one image per second to one image per 5 s. Cerebral blood flow (CBF), cerebral blood volume (CBV) and mean transit time (MTT) measurements were performed in identical regions of interest. Two neuroradiologists evaluated the PCT images visually to identify areas of abnormal perfusion. Perfusion images created up to a temporal resolution of one image per 3 s were rated to be diagnostically equal to the original data. Even at one image per 4 s, all areas of infarction were identified. Quantitative differences of CBF, CBV and MTT measurements were < or = 10% up to one image per 3 s. For PCT of the brain, temporal resolution can be reduced to one image per 3 s without significant compromise in image quality. This significantly reduces the radiation dose of the patient.

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Section: Methodsmentioning

confidence: 99%

“…Therefore, we studied the influence of the temporal resolution on the quantitative results of PCT measurements in stroke patients. For calculation of PCT measurements we used a mathematical algorithm not yet studied for its interaction with temporal resolution [11].…”

Section: Introductionmentioning

confidence: 99%

Dose reduction in dynamic perfusion CT of the brain: effects of the scan frequency on measurements of cerebral blood flow, cerebral blood volume, and mean transit time

et al. 2008

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“…A region of interest of the venous output function was also established on the superior sagittal sinus. The mean transit time (MTT) was obtained as a first moment of the residue function by using 3 types of deconvolution techniques: block-circulant singular value decomposition (SVD) (bSVD), which is theoretically delay insensitive 6 ; standard SVD (sSVD), which is widely used and known as delay sensitive [4][5][6] ; and box-modulation transfer function (bMTF), 7 which is delay-sensitive and used in many institutions in Japan. The threshold of the bSVD and sSVD was set as 20%.…”

Section: Ctp Study and Data Processingmentioning

confidence: 99%

Tracer Delay–Insensitive Algorithm Can Improve Reliability of CT Perfusion Imaging for Cerebrovascular Steno-Occlusive Disease: Comparison with Quantitative Single-Photon Emission CT

Sasaki¹,

Kudo²,

Ogasawara³

et al. 2008

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Reliability of CT perfusion (CTP) algorithms has not been fully validated. We investigated whether the cerebral blood flow (CBF) values obtained by using a dynamic CTP technique with a tracer delay-insensitive deconvolution algorithm are more accurate than those obtained by using CTP with delay-sensitive algorithms in unilateral cerebrovascular steno-occlusive disease, when compared with those generated by quantitative single-photon emission CT (SPECT).

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“…Dieser Parameter beschreibt die Zeit, die Blut für die Gewebspassage benötigt, und wird in Sekunden (oder Minuten) angegeben. Die MTT kann man berechnen über die Analyse der Fläche unter der Zeit-Dichte-Kurve (ratio of area to peak) [94], den geometrischen Schwerpunkt der Zeit-Dichte-Kurve (first moment, center of gravity) [3] oder über Dekonvolutionsverfahren [56,61].…”

Section: Zerebrales Blutvolumen (Cbv)unclassified

Zerebrale Perfusionsbildgebung mittels Mehrschichtspiral-CT

Wiesmann¹,

Böhner

Klingebiel

2004

Klinische Neuroradiologie

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ZusammenfassungDie CT-gestützte Perfusionsbildgebung (Perfusions-CT, PCT) hat in den letzten Jahren durch die Einführung der Mehrschichtspiraltechnik, die Verwendung von Untersuchungsprotokollen mit niedrigeren Injektionsraten und nicht zuletzt die Verfügbarkeit verbesserter Auswertungsprogramme wesentliche neue Impulse erhalten. Auf dem derzeitigen Stand der Technik ist die PCT mit nur geringem zusätzlichem Aufwand in der Routinediagnostik einsetzbar. Semiautomatische Auswertungsverfahren liefern innerhalb von Minuten quantitative Parameterbilder zur Beurteilung des zerebralen Perfusionsstatus. Damit ist die PCT zu einem wichtigen Bestandteil der Schlaganfallbildgebung geworden und liefert als solche über das mit der nativen CT bildmorphologisch erfassbare Ausmaß der Pathologie hinausreichende pathophysiologische Informationen. Durch die Kombination von nativer CT mit den verschiedenen Perfusionsparametern ist auch mit der CT eine relativ zuverlässige Unterscheidung zwischen irreversibel geschädigtem Infarktareal und der Infarktpenumbra möglich. Dadurch kann die PCT eine Wendung von rigiden therapeutischen Zeitfenstern hin zu einer prospektiv an den individuellen Perfusionsstatus adaptierten Behandlung unterstützen. Weitere Indikationsbereiche, wie die Differenzierung zerebraler Läsionen hinsichtlich ihrer Dignität, ihrer histopathologischen Graduierung, der intraläsionalen Verteilung vitaler und regressiver Tumoranteile für bioptische und therapeutische Zwecke sowie des Therapiemonitorings und der Rezidivkontrolle, sind derzeit Gegenstand der Forschung. Eine Perfusionsbildgebung in der Schlaganfalldiagnostik ist auch mit der MRT möglich. Für den Einsatz der PCT sprechen allerdings die bessere örtliche und zeitliche Verfügbarkeit der CT und der geringere Zeitaufwand der Untersuchung. Gerade für medizinische Einrichtungen ohne rund um die Uhr verfügbare MRT kann die PCT eine wertvolle Bereicherung des diagnostischen Spektrums darstellen. Schlüsselwörter: Computertomographie · Perfusionsbildgebung · CT-Perfusion · Schlaganfall · Zerebrovaskuläre Erkrankungen AbstractWithin the last few years, computed tomography techniques for assessing cerebral perfusion (perfusion CT, PCT) have been facilitated by the advent of multislice detector CT, protocols using lower injection rates, and the availability of improved evaluation software. Currently, PCT can be easily incorporated into the patient's routine CT examination. Semiautomatic commercial software packages are able to generate quantitative perfusion maps within minutes. Therefore, PCT has become a valuable tool in stroke imaging. Unlike conventional CT, which uses morphological information to assess cerebral pathology, PCT yields functional information on the perfusion status. If the information from a normal brain CT and perfusion parameter maps are combined, it is possible to discriminate between irreversibly damaged and potentially salvageable tissue. Thus, PCT can support therapeutic strategies based on individual assessment of brain perfusion in stroke patients ...

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A method of regional cerebral blood perfusion measurement using dynamic CT with an iodinated contrast medium

Cited by 29 publications

References 8 publications

Dose reduction in dynamic perfusion CT of the brain: effects of the scan frequency on measurements of cerebral blood flow, cerebral blood volume, and mean transit time

Dose reduction in dynamic perfusion CT of the brain: effects of the scan frequency on measurements of cerebral blood flow, cerebral blood volume, and mean transit time

Tracer Delay–Insensitive Algorithm Can Improve Reliability of CT Perfusion Imaging for Cerebrovascular Steno-Occlusive Disease: Comparison with Quantitative Single-Photon Emission CT

Zerebrale Perfusionsbildgebung mittels Mehrschichtspiral-CT

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