The GlideScope video laryngoscope has had a profound impact on clinical airway management by virtue of providing a glottic view superior to direct laryngoscopy. Since its introduction circa 2003, hundreds of studies have attested to its value in making clinical airway management easier and safer. This review will update the reader on the art and science of using the GlideScope videolaryngoscope in a variety of clinical settings and its relation to other airway management products. Topics covered include GlideScope design considerations, general usage tips, use in obese patients, use in pediatric patients, use as an adjunct to fiberoptic intubation, and other matters. Complications associated with the GlideScope are also discussed.