The origin–destination (OD) matrix is a critical tool in understanding human mobility, with diverse applications. However, constructing OD matrices can pose significant privacy challenges, as sensitive information about individual mobility patterns may be exposed. In this paper, we propose DistOD, a hybrid privacy-preserving and distributed framework for the aggregation and computation of OD matrices without relying on a trusted central server. The proposed framework makes several key contributions. First, we propose a distributed method that enables multiple participating parties to collaboratively identify hotspot areas, which are regions frequently traveled between by individuals across these parties. To optimize the data utility and minimize the computational overhead, we introduce a hybrid privacy-preserving mechanism. This mechanism applies distributed differential privacy in hotspot areas to ensure high data utility, while using localized differential privacy in non-hotspot regions to reduce the computational costs. By combining these approaches, our method achieves an effective balance between computational efficiency and the accuracy of the OD matrix. Extensive experiments on real-world datasets show that DistOD consistently provides higher data utility than methods based solely on localized differential privacy, as well as greater efficiency than approaches based solely on distributed differential privacy.