The drive at the center of gravity (DCG) concept-based twin-ball-screw drive mechanism (TBSDM) is vital in automated factories for its robustness and reliability. However, changes in the worktable mass or position result in changes in the center of gravity (CG), significantly affecting the system’s dynamic properties. In this regard, this paper introduces a novel analytical model using improved receptance coupling to analyze vibrations in four modes. A mathematical framework for the twin TBSDM is generated, and the effect of changing the worktable position–mass on each mode is examined. The applicability of the proposed method is verified based on dynamic experiments that were carried out on a TBSDM of a CNC grinding wheel machine tool. After thoroughly analyzing the experimental and theoretical results, it is revealed that changing the worktable position primarily influences the rotational and axial vibrations of the twin ball screw (TBS). Furthermore, changes in the worktable mass significantly affect the coupling vibration among the TBSs and rotors or bearings. Moreover, in terms of performance, the variances between the theoretical and experimental natural frequencies are consistently below 5%. Thus, the proposed method is promising for the improvement of the modeling and analysis of the TBSDM.