Objective: To compare the erosive effect of a new blackcurrant/calcium drink with xanthan gum, on enamel in situ, with a low erosive product, a conventional fruit beverage and water. Design: The study was single centre, randomised, single blind, 4 treatment crossover design. Setting: This study, conducted in 2000, employed volunteers working at the Bristol Dental Hospital, UK. Subjects, materials and methods: 16 subjects (≥18 years) wore two enamel samples in a removable acrylic appliance. The drinks tested were (A) New blackcurrant/calcium/gum drink (test product), (B) Original blackcurrant/calcium drink, (C) Conventional blackcurrant drink (positive control) and (D) Water (negative control), for 15 day study periods. Drinking was supervised, with 250 ml imbibed four times/day between 9.00am-5.00pm. Profile measurements of specimens were made at baseline, 5, 10 and 15 days. Main outcome measures: Paired t-tests compared erosion by surfometry with selected pairs of formulations. Results: Of 16 screened subjects (3 male, 13 female), mean age 34.2 years, 1 subject failed to complete the study. A caused significantly less enamel loss than C, with no statistically significant differences from B at any time points measured. Of 43 treatment emergent adverse events, none were considered related to the study formulations. Conclusions: A retained low erosive properties similar to B, with additional benefits of taste flexibility and beverage stability. A number of peer reviewed epidemiological studies in the dental literature 1-5 highlight the presence of erosion in our population, particularly in the younger generations. However, as yet no longitudinal data are available to support these clinical observations. A recent paper corroborated these findings, showing that approximately half of 14-year-olds have appreciable tooth wear and significant erosion. 6 Interestingly, this was found to be more prevalent in lower socio-economic groups. 6 Retail sales of soft drinks indicate a rise in consumption of 2-3% each year from 1986 to date and future projections suggest this trend will continue. 7 The volume of soft drinks imbibed does correlate to some degree with the level of erosion observed. 8 However, controlled studies have shown that susceptibility to erosion under similar exposure varies considerably. 9,[12][13][14] Other factors, mainly physical, including abrasion and erosion, will also modify the level of toothwear that occurs although the interaction of chemical and physical wear processes have received limited attention using in vitro methods and none in vivo. For those individuals who are susceptible to erosion, tooth loss can be rapid. Ideally, and hopefully in the not too distant future, such susceptible individuals will be identifiable before excessive hard tissue loss occurs and allow for the provision of appropriate dietary advice or medical intervention. In the meantime the development of low erosive beverages, that appeal to our organoleptic senses, will undoubtedly be extremely useful for these vulnerable pe...