In this paper, the optimization of medium and control characteristics of stimulated Brillouin scattering (SBS) based on mixed media is investigated. The excellent intersolubility of perfluorocarbon liquid media is analyzed and the dependence of gain coefficient, phonon lifetime and Brillouin frequency shift of HT-230/FC-72 mixed media on mixing-ratio is numerically simulated. In Countinuum’s Nd: YAG seed-injected laser system, we measured absorption coefficient, optical breakdown threshold, energy reflectivity and Stokes pulses waveform of HT-230/FC-72 mixture under different mixing-ratio. The results indicate that the mixed media not only can optimize the medium, but also can control the characteristics of SBS within a certain range.