Gradient colored yarns are manufactured by controlling the blending ratios of three-primary-colored fibers in a slight distribution of gradients along the yarn length, thereby resulting in a continuous natural variation in mixed colors of the fibers throughout the whole yarn. The spinning of gradient colored yarns still remains a challenge, which requires the reliance on digital blending theory of colored fibers and the supporting of multi-channel computer numerical control (CNC) spinning technique. This paper constructed a three-primary-colored fiber gridded color mixing model and its mass mixing matrix and color mixing chromatography matrix by mass discretization and coupling pairing with a 10% gradient for the three-primary-colored fibers. With the aim of continuous natural gradient of mixed colors, the blending ratio gradient path of three-primary-colored fibers was planned based on the mass mixing matrix, and a method of regulating the gradient of color difference between adjacent color segments was proposed. In order to realize the natural gradient of color of the forming yarn, the spinning mechanism of gradient colored yarn was established based on three-channel CNC spinning mechanism and the time-series yarn simulation model, and the time-series spinning processing parameters of three-channel CNC spinning machine were devised. Four gradient colored yarns with different gradient paths were designed and prepared, the linear density, twist, unevenness, surface hairiness, and tensile strength of the spun yarns were measured, compared, and analyzed, and knitted fabrics with color gradient effect were fabricated by small circular knitting machine to obtain continuous and natural color transition with a dreamy and mysterious color effect.