Sustainable mobility strategies in the locale could facilitate cultural routes' social, economic, cultural, and environmental mandates. The purpose of this article is to explore the beneficial practices of sustainable mobility on cultural routes through a systematic literature review. The ultimate objective is to summon the sustainable mobility strategies implemented on cultural routes that could positively affect the economic, social, environmental, and cultural environments of a destination. A systematic literature review was initiated through the protocol of the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses methodology. The meta‐synthesis approach resulted in identifying five sustainable mobility policy recommendations suitable for cultural route development. Slow mobility practices, drive tourism, mobility infrastructures along cultural routes, accessibility into cultural routes, and urban mobility are fundamental for the creation of an efficient sustainable mobility plan to support cultural routes and achieve a sustainable tourism future for regions.