the world's energy. [1,2] Considering the energy efficiency impact of an indoor set-point temperature, 1.5% of the total energy consumption for HVAC per 1° of Fahrenheit change, [3,4] a significant energy conservation opportunity exists. Designing and operating HVAC systems in an energy-efficient manner to meet low-energy targets are therefore essential. [5] Several studies have suggested that significant energy savings can be achieved by using feedback from sensorbased occupancy detection when operating HVAC systems. [6][7][8][9] These studies demonstrate a significant theoretical energy-saving potential, i.e., when perfect occupancy detection and predictions are assumed. However, the accuracy of occupancy detection and predictions significantly affects the theoretical energysaving potential. [10] This issue calls for the development of reliable yet simple and inexpensive real-time occupancy detection approaches to include occupancy information when optimizing real-time HVAC operation. In recent years, various types of occupancy detection methods have been developed using tools such as passive infrared sensors, [11] cameras, [12] wireless sensor networks, [13] radio frequency identification sensors, [14,15] and CO 2 sensors, [16][17][18] among Heating, ventilation, and air conditioning systems in building operations have extensively gained significant interest in recent years for providing a comfortable environment and energy savings by utilizing the occupancy information of buildings. Herein, a flexible heterogeneous temperature and humidity sensor-based occupancy detection device with an integrated wireless communication system is introduced. The multichannel (threechannel) Pt-based temperature and single-channel humidity sensors afford excellent electrical conductivity, exceptional linearity, and high mechanical flexibility. The presented occupancy detection device design contains a multichannel temperature sensor, an interdigitated humidity sensor, a customized signal processing integrated circuit, a flexible battery, and a wireless communication system, which can be used to perform occupancy trials in offices. The proposed occupancy detection device is mounted on an office chair to analyze the environmental changes according to the user's activities and to address the challenge of long-term continuous monitoring of temperature and humidity for managing the energy consumption in the building operations. The presented occupancy detection device provides a new platform for introducing a flexible device system to collect the actual occupancy information and is a new step toward "smart office" applications.