A methodology for specifying PET VOIs using multimodality techniques

Klein, Gregory; Teng, X.; Jagust, W.J.; Eberling, Jamie L.; Acharya, Ananth; Reutter, B.W.; Huesman, R.H.

doi:10.1109/42.611350

Cited by 31 publications

(21 citation statements)

References 28 publications

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“…Regions were drawn on data in native space to preserve differences in tracer uptake caused by anatomical variability between subjects. We have previously demonstrated the ability to draw ROIs with high inter-rater reliability (Klein et al, 1997). The Patlak model was fitted with dynamic data from each ROI from 24 to 89 min, when the regression is highly linear (r Ͼ0.99).…”

Section: Methodsmentioning

confidence: 99%

Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum

Cools¹,

Gibbs²,

Miyakawa³

et al. 2008

J. Neurosci.

290

261

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Evidence from psychopharmacological research has revealed that dopamine receptor agents have opposite effects on cognitive function depending on baseline levels of working memory capacity. These contrasting effects have been interpreted to reflect differential baseline levels of dopamine. Here we demonstrate for the first time that working memory capacity as measured by listening span predicts dopamine synthesis capacity in the striatum, indicating that subjects with low working memory capacity have low DA synthesis capacity in the striatum, whereas subjects with high working memory capacity have high DA synthesis capacity in the striatum.

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Section: Methodsmentioning

confidence: 99%

Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum

Cools¹,

Gibbs²,

Miyakawa³

et al. 2008

J. Neurosci.

290

261

View full text Add to dashboard Cite

show abstract

“…Hippocampal volumes were drawn by a single rater blind to subject classification using an in-house program to create a volume out of the areas traced on contiguous slices [36]. Volumes for a subset of subjects were drawn twice by two raters in order to determine inter-and intra-rater reliability using intraclass correlations.…”

Section: Mr Data Acquisition and Analysismentioning

confidence: 99%

Preliminary evidence that estrogen protects against age-related hippocampal atrophy

Eberling¹,

Wu²,

Haan³

et al. 2003

Neurobiology of Aging

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Few studies have examined gender differences in hippocampal volumes, and the potential effect of estrogen on these measures has not been well studied. We used MRI to measure hippocampal volumes in elderly Mexican American men and women subjects in order to determine if there were gender differences and if estrogen replacement therapy (ERT) had an effect on hippocampal volume in postmenopausal women. MRI measures of hippocampal volumes (normalized to intracranial volume) were compared in 59 women and 38 men. Further comparisons were made between men subjects, women subjects taking ERT, and women subjects not taking ERT. There were no significant effects of gender on normalized hippocampal volumes. However, women subjects taking ERT had larger right hippocampal volumes than women subjects not taking ERT and larger anterior hippocampal volumes than men subjects and women subjects not taking ERT. These findings suggest a neuroprotective effect of estrogen.

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“…Using the program VIDA (Klein et al, 1997), a volume of interest (VOI) approach was used to delineate the boundaries of the right and left hippocampus (RHC, LHC), temporal lobe (RTL, LTL), and parahippocampal gyrus (RPHG, LPHG; see Figure 1). First the T1-weighted coronal dataset was resliced and aligned perpendicular to the long axis of the left hippocampus.…”

Section: Volume Of Interest Analysesmentioning

confidence: 99%

Correlates of memory function in community-dwelling elderly: The importance of white matter hyperintensities

Petkov

Eberling

et al. 2004

J. Inter. Neuropsych. Soc.

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We sought to identify magnetic resonance-(MR)-imaged structures associated with declarative memory in a community-dwelling sample of elderly Mexican-American individuals with a spectrum of cognitive decline. Measured structures were the hemispheric volumes of the hippocampus (HC), parahippocampal gyrus, and remaining temporal lobes, as well as severity of white matter signal hyperintensities (WMH). Participants were an imaged subsample from the Sacramento Area Latino Study of Aging (SALSA), N 5 122. Individuals were categorized as normal, memory impaired (MI), cognitively impaired non-demented (CIND), or demented. We show that WMH was the strongest structural predictor for performance on a delayed free-recall task (episodic memory) in the entire sample. The association of WMH with delayed recall was most prominent in elderly normals and mildly cognitively impaired individuals with no dementia or impairment of daily function. However, the left HC was associated with verbal delayed recall only in people with dementia. The right HC volume predicted nonverbal semantic-memory performance. We conclude that WMH are an important pathological substrate that affects certain memory functions in normal individuals and those with mild memory loss and discuss how tasks associated with WMH may rely upon frontal lobe function. (JINS, 2004, 10, 371-381.)

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A methodology for specifying PET VOIs using multimodality techniques

Abstract: Abstract-Volume-of-interest (VOI) extraction for radionuclide and anatomical measurements requires correct identification and delineation of the anatomical feature being studied. We have developed a toolset for specifying three-dimensional (

Cited by 31 publications

References 28 publications

Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum

Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum

Preliminary evidence that estrogen protects against age-related hippocampal atrophy

Correlates of memory function in community-dwelling elderly: The importance of white matter hyperintensities

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