A Mg/Zn-co-doped composite coating on a titanium surface enhances osteogenic activity through the Wnt/β-catenin pathway

Zhao, Qing; Xu, Guanhua; Hu, Annan; Xu, Ruirong; Jin, Huricha; Sun, Yuyu; Bao, Guofeng; Yuan, Kun; Zhou, Xiaogang; Wang, Xing; Cui, Zhiming

doi:10.1016/j.apsusc.2020.146072

Cited by 10 publications

(3 citation statements)

References 35 publications

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“…PEO is a commonly used surface treatment technology, which improves the biological performance of a Ti implant. ,, Recent studies have revealed that Li has a positive influence on immune regulation for osteointegration and induces exosome secretion that promotes angiogenesis. , In this study, we studied the direct influence of Li-doped PEO-coated Ti on rat bone marrow mesenchymal stem cells (rBMSCs). Surface views of various prepared samples are shown in Figure a.…”

Section: Resultsmentioning

confidence: 99%

“…Surface modification technologies such as plasma electrolytic oxidation (PEO), spray coating, and plasma immersion ion implantation have been applied on Ti surfaces to alter their topological morphology and phase composition and thus to improve their biological performances. ,− In particular, PEO has been considered as an economical and effective electrochemical surface modification method, which can produce surfaces with porous structures and alterative compositions . By changing the composition of electrolytes, the PEO coating can be loaded with various bioactive ions such as argentum (Ag), calcium (Ca), and strontium (Sr). ,, These bioactive ions play curial roles in the behavior of cells with bones.…”

Section: Introductionmentioning

confidence: 99%

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Li-Doped Ti Surface for the Improvement of Osteointegration

et al. 2022

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Aseptic loosening is the main factor that leads to the failure of orthopedic implants. Enhancing the early osteointegration of a bone implant can lower the risk of aseptic loosening. Here, a Li-doped surface was constructed on a Ti surface via plasma electrolytic oxidation (PEO) to improve osteointegration. The prepared Li-doped PEO coating showed a porous morphology and the sustained release of Li ions. In vitro results of rat bone marrow mesenchymal stem cell (rBMSC) culture studies suggested that the Li-doped Ti surface significantly favored cell adhesion. Moreover, it was found that the Li-doped surface enhanced alkaline phosphatase activity and extracellular matrix mineralization of rBMSCs. In addition, the surface improved the expression of osteogenesis-related genes. Furthermore, a bone implantation model indicated that the Li-doped Ti surface showed improved osteointegration. The incorporation of Li into a Ti surface is a promising method for orthopedic applications.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Li-Doped Ti Surface for the Improvement of Osteointegration

et al. 2022

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“…On the other hand, the underlying mechanisms of cell behaviors, especially osteogenic behaviors, stimulated by modified surface of Ti remain poorly understood. Several studies have demonstrated the differential expression of RNAs or proteins in specific signaling pathways were related their involvement in cell behaviors [ [21] , [22] , [23] ]. For example, Wang et al found that the expression of p-FAK, p-ERK, p-P38, and p-JNK proteins in rBSMCs were upregulated when cultured on polydopamine-coated polyetheretherketone (PEEK), and concluded that polydopamine could enhance the osteogenic differentiation of rBMSCs through FAK and p38 signaling pathways [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced osteogenesis of titanium with nano-Mg(OH)2 film and a mechanism study via whole genome expression analysis

Yao

Cheng

Zhou

et al. 2021

Bioactive Materials

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Titanium (Ti) has been the most widely used orthopedic implant in the past decades. However, their inert surface often leads to insufficient osteointegration of Ti implant. To solve this issue, two bioactive Mg(OH) 2 films were developed on Ti surfaces using hydrothermal treatment (Ti-M1# and Ti-M2#). The Mg(OH) 2 films showed nano-flake structures: sheets on Ti-M1# with a thickness of 14.7 ± 0.7 nm and a length of 131.5 ± 2.9 nm, and on Ti-M2# with a thickness of 13.4 ± 2.2 nm and a length of 56.9 ± 5.6 nm. Both films worked as Mg ions releasing platforms. With the gradual degradation of Mg(OH) 2 films, weakly alkaline microenvironments will be established surrounding the modified implants. Benefiting from the sustained release of Mg ions, nanostructures, and weakly alkaline microenvironments, the as-prepared nano-Mg(OH) 2 coated Ti showed better in vitro and in vivo osteogenesis. Notably, Ti-M2# showed better osteogenesis than Ti-M1#, which can be ascribed to its smaller nanostructure. Moreover, whole genome expression analysis was applied to study the osteogenic mechanism of nano-Mg(OH) 2 films. For both coated samples, most of the genes related to ECM-receptor interaction, focal adhesion, and TGF-β pathways were upregulated, indicating that these signaling pathways were activated, leading to better osteogenesis. Furthermore, cells cultured on Ti-M2# showed markedly upregulated BMP-4 gene expression, suggesting that the nanostructure with Mg ion release ability can better activate BMP-4 related signaling pathways, resulting in better osteogenesis. Nano-Mg(OH) 2 films demonstrated a superior osteogenesis and are promising surface modification strategy for orthopedic applications.

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Endowing biodegradable Zinc implants with dual-function of antibacterial ability and osteogenic activity by micro-addition of Mg and Ag (≤ 0.1 wt.%)

Chen

Zhao

et al. 2023

Acta Biomaterialia

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A Mg/Zn-co-doped composite coating on a titanium surface enhances osteogenic activity through the Wnt/β-catenin pathway

Cited by 10 publications

References 35 publications

Li-Doped Ti Surface for the Improvement of Osteointegration

Li-Doped Ti Surface for the Improvement of Osteointegration

Enhanced osteogenesis of titanium with nano-Mg(OH)2 film and a mechanism study via whole genome expression analysis

Endowing biodegradable Zinc implants with dual-function of antibacterial ability and osteogenic activity by micro-addition of Mg and Ag (≤ 0.1 wt.%)

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