A microbially based approach for the asymmetric synthesis of both enantiomers of <i>R</i>‐ and <i>S</i>‐fluoxetine

顾建新,; 李祖义,; 林国强,

doi:10.1002/cjoc.19920100411

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Chemo-enzymatic Synthesis1

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Cited by 5 publications

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“…Chemical enantiomeric routes to fluoxetine have been described by Sharpless (Gao and Sharpless, 1988), using selective reduction of 2,3-epoxycinnamoyl alcohol with Red-Al, and by Corey and Reichard, (1989), comprising the CBS enantiomeric catalytic reduction process, respectively. With the aid of microorganisms, we have accomplished the synthesis of both enantiomers of fluoxetine in good yields with high optical purities (Gu et al, 1992). Ethyl benzoyl acetate 54 was fermented with baker's yeast or Geotrichum sp.…”

Section: Chemo-enzymatic Synthesismentioning

confidence: 99%

Chiral Drugs and the Associated Asymmetric Synthesis

Zhang

Lin

2006

Drug Discovery Research

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Section: Chemo-enzymatic Synthesismentioning

confidence: 99%

Chiral Drugs and the Associated Asymmetric Synthesis

Zhang

Lin

2006

Drug Discovery Research

View full text Add to dashboard Cite

Asymmetric Syntheses Aided by Biocatalysts

et al. 2003

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This a d d e mnmarks the achievements of the authors' groupin the area of biocatalyst-catalyzd organic reactions in recent 10 years. A strain of Gtohichum sp. obtained by screening is capable of stereoselectively reducing a number of carbonyl ampounds. In many cases, the stereochemistry is complementary d t h that obtained by baker ' s yeast. Therefore, this microorganism provides a useful pathway to the preparation of dcohol compounds with specil'lc configurations. On the other hand, a number of plant sources have been screened for oxpnitrilases and the hydrocyanation reactions of various arylcarboxaldehydes have been investigated. A "micro-aqueous d o n system" ww invented. by which a series of novel optically active cyanohydrinq were prepared. On this basis, a high through-put continuous reaction system bas been designed. This paper also describes exampla of the syntheses of bio-active compounds by Using the optically active compounds obtained From the abovementioned catalytic reactions as precursors. , IC~YWOIYIS asymmetric synthesis, biocatalyst, Ceohichwn sp., stereoselective reduction, oxynitrilase , enantioselective hydrocyanation *

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Reductive biotransformations of 2-substituted-3-carbonyl butanoate by resting cells and an enzymatic system of Geotrichum sp.

Bingfeng

Jianxing

et al. 1995

Enzyme and Microbial Technology

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A microbially based approach for the asymmetric synthesis of both enantiomers of R‐ and S‐fluoxetine

Cited by 5 publications

References 8 publications

Chiral Drugs and the Associated Asymmetric Synthesis

Chiral Drugs and the Associated Asymmetric Synthesis

Asymmetric Syntheses Aided by Biocatalysts

Reductive biotransformations of 2-substituted-3-carbonyl butanoate by resting cells and an enzymatic system of Geotrichum sp.

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