A Microbiological Epilogue—Nosocomial Infections

Roșca, Irina; Ursu, Elena-Laura; Fifere, Adrian

doi:10.1007/978-3-030-57456-7_9

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…The PCA antioxidant action comes from the property of scavenging free radicals by donating hydrogen atoms or electrons [ 24 ], whereas the antibacterial activity is due to the action of decreasing lipid oxidation levels [ 25 ], and its antiviral property is due to the replication of the hepatitis B virus [ 26 ]. Our group also loaded unstable and insoluble PCA into magnetic cargo complexes under mild conditions using a simple and reproducible approach to increase its bioavailability and its continuous pharmaceutical effects, by releasing it for more than three days [ 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?

Fifere¹,

Turin-Moleavin²,

Roșca³

2022

Life

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The aim of this study is to evaluate the efficiency of protocatechuic acid (PCA) in enhancing the commonly used drugs used to fight against nosocomial infection. These drugs are represented by routinely used antibiotics, synthetic chemotherapeutic agents with an antimicrobial spectrum, and antifungals. Three concentrations of PCA were added to 12 types of commercial disks used for antibiotic and antifungal susceptibility and tested against bacterial and yeast strains represented by Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. The results proved that PCA increased up to 50% of the antibacterial activity, especially that of levofloxacin against Staphylococcus aureus and Escherichia coli. These formulations will lead to new drug design ideas containing a smaller amount of antibiotics with the same effectiveness.

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Section: Introductionmentioning

confidence: 99%

Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?

Fifere¹,

Turin-Moleavin²,

Roșca³

2022

Life

Self Cite

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Long-term effectiveness of commonly used hospital disinfectants against Pseudomonas aeruginosa and Staphylococcus aureus

Odonkor¹,

Mahami²,

Sallar³

2021

Afr. J. Microbiol. Res.

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Nosocomial infections are enhanced due to a flop in the infection control processes such as disinfection. The aim of this study was to assess long term effectiveness and the stability of disinfectants currently used within healthcare settings in Accra, Ghana against two indicator pathogens. Two locally produced and two imported disinfectants usually used in health care settings were obtained. The efficacy and long-term stability of the disinfectants was done using the in-use method, with identified microbial culture isolates of Pseudomonas aeruginosa and Staphylococcus aureus. Counts of both test organisms (Pseudomonas aeruginosa and Staphylococcus aureus) were over and above the 5 ≥ CFU recommended standard. All the disinfectants failed the test. However, contamination was observed to be higher in local disinfectants as compared to those imported. Furthermore, Enterobacter spp was isolated as contaminant from one imported disinfected and Proteus spp was also isolated from one local disinfectant. Interestingly, one of the imported disinfectants (Disinfectant I) showed more stability and was effective in the long term. All disinfectants did not pass the in-use test. However, disinfectants that are produced locally are more unstable and ineffective.

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A Microbiological Epilogue—Nosocomial Infections

Cited by 2 publications

References 39 publications

Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?

Does Protocatechuic Acid Affect the Activity of Commonly Used Antibiotics and Antifungals?

Long-term effectiveness of commonly used hospital disinfectants against Pseudomonas aeruginosa and Staphylococcus aureus

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