2006
DOI: 10.1007/s00216-006-0776-8
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A microchip sensor for calcium determination

Abstract: A newly designed glass-PDMS microchip-based sensor for use in the determination of Ca(2+) ions has been developed, utilizing reflectance measurements from arsenazo III (1,8-dihydroxynaphthalene-3,6-disulfonic acid-2,7-bis[(azo-2)-phenyl arsenic acid]) immobilized on the surface of polymer beads. The beads, produced from cross-linked poly(p-chloromethylstyrene) (PCMS), were covalently modified with polyethylenimine (PEI) to which the Arsenazo III could be adsorbed. The maximum amount of Arsenazo III which could… Show more

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Cited by 32 publications
(18 citation statements)
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“…The limit of detection (LOD) of Ca(II), defined as the concentration equivalent to a signal of blank plus three times the standard deviation of the blank, was calculated to be 0.15 mg⋅L -1 in the low concentration range of linearity. The sensitivity of the proposed method in terms of lowering the LOD of Ca-sensing was better than those of recent analog sensors manufactured by Caglar et al [12] and Malcik et al [13]. The proposed sensing method was validated against flame-AAS analysis of known complex samples of Ca.…”
Section: Analytical Characteristic Of the Sensormentioning
confidence: 94%
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“…The limit of detection (LOD) of Ca(II), defined as the concentration equivalent to a signal of blank plus three times the standard deviation of the blank, was calculated to be 0.15 mg⋅L -1 in the low concentration range of linearity. The sensitivity of the proposed method in terms of lowering the LOD of Ca-sensing was better than those of recent analog sensors manufactured by Caglar et al [12] and Malcik et al [13]. The proposed sensing method was validated against flame-AAS analysis of known complex samples of Ca.…”
Section: Analytical Characteristic Of the Sensormentioning
confidence: 94%
“…Accordingly, the addition of KCN to the medium is not needed. In various samples assayed with a sensor [12][13][14], Mg(II) at concentrations exceeding 4-to 5-fold was reported to interfere with the determination of calcium. On the other hand, with the proposed technique, Mg(II) was shown not to interfere even at 100-fold (by wt.)…”
Section: Interferencesmentioning
confidence: 99%
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“…Compared with electrochemical detectors, optical detectors are more sensitive and reproducible. Different optical methods were also employed in microchips to detect metal ions, including absorbance (Malcik et al 2005;Du et al 2005), reflectance (Caglar et al 2006), chemiluminescence (Liu et al 2003), photodiode array detection (Collins and Lu 2001), and colorimetric methods (Deng and Collins 2003). Currently, the most sensitive optical detection method is based on Laser-induced Fluorescence (LIF) (Xu, Li, and Weber 2007).…”
Section: Introductionmentioning
confidence: 99%