A microemulsion-based gel of isotretinoin and erythromycin estolate for the management of acne

Alam, Aftab; Mustafa, Gulam; Agrawal, Gopal Prasad; Hashmi, Sana; Khan, R. A.; Alkhayl, Faris F. Aba; Ullah, Zabih; Ali, Mohammed Ashraf; Elkirdasy, Ahmed F.; Khan, Shamshir

doi:10.1016/j.jddst.2022.103277

Cited by 12 publications

(9 citation statements)

References 34 publications

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“…The developed microemulsion-based hydrogel system, as compared to conventional products, exhibited increased permeation efficiency and more deposition across the layers of rodent skin for encapsulated drugs and enhanced the in vitro efficacy against C. acnes . Therefore, the formulated system could be a promising carrier for the topical application of both encapsulated therapeutic agents along with management of acne in a simple, effective, and safer approach . Kashani-Asadi-Jafari et al formulated topical liposomes encapsulated with doxycycline hyclate for the treatment of acne and also to prevent the side effects of loaded drugs on oral administration.…”

Section: Treatment Approaches For Various Disorders Using Topical Dru...mentioning

confidence: 99%

“…Therefore, the formulated system could be a promising carrier for the topical application of both encapsulated therapeutic agents along with management of acne in a simple, effective, and safer approach. 95 Kashani-Asadi-Jafari et al formulated topical liposomes encapsulated with doxycycline hyclate for the treatment of acne and also to prevent the side effects of loaded drugs on oral administration. The prepared drug-loaded formulation exhibited increased activity against the main acne-causing bacterial strain and improved cell viability with almost three times more deposition in dermal layers of rat skin and nontoxicity to human dermal fibroblasts relative to free drug.…”

Section: Treatment Approaches For Various Disorders Using Topical Dru...mentioning

confidence: 99%

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New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

et al. 2023

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Skin, the largest organ in humans, is an efficient route for the delivery of drugs as it circumvents several disadvantages of the oral and parenteral routes. These advantages of skin have fascinated researchers in recent decades. Drug delivery via a topical route includes moving the drug from a topical product to a locally targeted region with dermal circulation throughout the body and deeper tissues. Still, due to the skin's barrier function, delivery through the skin can be difficult. Drug delivery to the skin using conventional formulations with micronized active components, for instance, lotions, gels, ointments, and creams, results in poor penetration. The use of nanoparticulate carriers is one of the promising strategies, as it provides efficient delivery of drugs through the skin and overcomes the disadvantage of traditional formulations. Nanoformulations with smaller particle sizes contribute to improved permeability of therapeutic agents, targeting, stability, and retention, making nanoformulations ideal for drug delivery through a topical route. Achieving sustained release and preserving a localized effect utilizing nanocarriers can result in the effective treatment of numerous infections or skin disorders. This article aims to evaluate and discuss the most recent developments of nanocarriers as therapeutic agent vehicles for skin conditions with patent technology and a market overview that will give future directions for research. As topical drug delivery systems have shown great preclinical results for skin problems, for future research directions, we anticipate including in-depth studies of nanocarrier behavior in various customized treatments to take into account the phenotypic variability of the disease.

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Section: Treatment Approaches For Various Disorders Using Topical Dru...mentioning

confidence: 99%

Section: Treatment Approaches For Various Disorders Using Topical Dru...mentioning

confidence: 99%

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

et al. 2023

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“…ERY microemulsion -based hydrogel was prepared using isopropyl myristate oil and Tween 80 surfactant to first prepare the ERY microemulsion which was then stabilized into Carbopol and triethanolamine to form the gel [ 141 ]. Along with ERY, isotretinoin was encapsulated, in order to investigate their synergism.…”

Section: Gelsmentioning

confidence: 99%

Erythromycin Formulations—A Journey to Advanced Drug Delivery

2022

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Erythromycin (ERY) is a macrolide compound with a broad antimicrobial spectrum which is currently being used to treat a large number of bacterial infections affecting the skin, respiratory tract, intestines, bones and other systems, proving great value from a clinical point of view. It became popular immediately after its discovery in 1952, due to its therapeutic effect against pathogens resistant to other drugs. Despite this major advantage, ERY exhibits several drawbacks, raising serious clinical challenges. Among them, the very low solubility in water and instability under acidic conditions cause a limited efficacy and bioavailability. Apart from this, higher doses promote drug resistance and undesirable effects. In order to overcome these disadvantages, during the past decades, a large variety of ERY formulations, including nanoparticles, have emerged. Despite the interest in ERY-(nano)formulations, a review on them is lacking. Therefore, this work was aimed at reviewing all efforts made to encapsulate ERY in formulations of various chemical compositions, sizes and morphologies. In addition, their preparation/synthesis, physico-chemical properties and performances were carefully analysed. Limitations of these studies, particularly the quantification of ERY, are discussed as well.

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“…As presented in Table 1, the maximum density was given by red inorganic pigment as well as refractive index and turbidity. 29 It could be explained; because the number of materials added to the system was higher, resulting in an increasing number of components. On the other hand, the lowest density, refractive index, and turbidity were given by yellow pigments.…”

Section: Solubility Studies Of Inorganic Pigments In the Microemulsio...mentioning

confidence: 99%

Fabrication of ballpoint-ink via encapsulating inorganic pigments in microemulsion gels

et al. 2022

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A microemulsion-based gel of isotretinoin and erythromycin estolate for the management of acne

Cited by 12 publications

References 34 publications

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

New Insights in Topical Drug Delivery for Skin Disorders: From a Nanotechnological Perspective

Erythromycin Formulations—A Journey to Advanced Drug Delivery

Fabrication of ballpoint-ink via encapsulating inorganic pigments in microemulsion gels

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