A microfluidic chip integrated with molecular imprinting polymers for surface plasmon resonance detection

Abstract

This paper reports a novel microfluidic chip integrated with molecular imprinting polymers (MIP) for surface plasmon resonance (SPR) detection of specific label-free bio-samples. The innovative microfluidic biochip is capable of transporting a specific amount of bio-samples inside ' multiple microchannels using micropumps/microvalves to sensing regions where multiple MIP films are locally deposited such that highly -sensitive, highly-specific bio -sensing could be achieved. With the help of SPR sensing techniques, the microfluidic biochips have the potential to be widely used for bio-sensing applications. While compared to other sensing techniques, the developed system has several advantages, including labeling-free, high sensitivity, capability of quantitative analysis of nano-scale bio-molecules in reakime fashion.